Ravizza S.p.a.

Francesco Mauri

Roberto Signorini

A process for preparing 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one of the formula: ##STR1## utilizing 2',5-dichloro-2-aminobenzophenone, phthalimidoglycine and hydrazine in a single passage and in a single reaction medium under critical reaction conditions.

Process for preparing a 7-chloro-5-(2-chlorophenyl)-benzodiazepinone

The application describes a process for preparing 2-phenyl derivatives of benzoxazolyl propionic acid of formula ##STR1## in which X is H, Cl, Br, F, or a linear or branched alkyl or 1 to 6 carbon atoms. The process starts from 3-nitro-4-hydroxyphenyl-.alpha.-methyl-acetonitrile which is hydrolysed in the presence of a strong acid, the 3-nitro-4-hydroxyphenyl-.alpha.-methylacetic acid thus obtained is hydrogenated in the presence of Pd on carbon, and the 3-amino-4-hydroxyphenyl-.alpha.-methylacetic acid deriving therefrom is first reacted with benzoyl chloride or with para-substituted benzoyl chloride in the presence of an alkaline base, and then with 85% phosphoric acid to complete the formation of the oxazolinic ring.

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Monza, Italy

Francesco Mauri