Carlo Erba S.p.a.

Farmitalia Carlo Erba S.p.a.

Francesco Lauria

Gianfederico Doria

Maria L Corno

Marcello Tibolla

PierNicola Giraldi

Piero Sberze

Ciriaco Romeo

Piero Melloni

Alessandro Rossi

Raffaele Tommasini

Arturo Della Torre

Norina Passerini

Nicola Mongelli

Marcellino Tibolla

Pier Nicola Giraldi

Giriaco Romeo

3,4-Dihydro-quinazoline derivatives, such as 6-carboxy-2-(2'-ethoxy-phenyl)-3,4-dihydro-4-oxo-quinazoline, are disclosed. The compounds possess anti-allergy properties and can be used for the treatment of allergic conditions.

3,4-Dihydro-quinazoline derivatives

Substituted 2-vinyl-chromones are disclosed, wherein the chromone ring has an alkyl or alkenyl substituent at the 3-position, and a styryl substituent at the 2-position. The compounds exhibit anti-allergy activity and can be used to treat allergic conditions.

Substituted 2-vinyl-chromones and process for their preparation

Substituted 2-vinyl chromones are disclosed, wherein the chromone ring has an alkyl or alkenyl substituent at the 3-position, and a styryl substituent at the 2-position. The compounds exhibit anti-allergy activity and can be used to treat allergic conditions.

Substituted 2-vinyl chromones are disclosed, wherein the chromone ring has an alkyl or alkenyl substituent at the 3-position, and a pyridyl-vinyl substituent at the 2-position. The compounds exhibit anti-allergy activity and can be used to treat allergic conditions.

Substituted 2-vinyl chromones are disclosed, wherein the chromone ring has an alkyl or alkenyl substituent at the 3-position, and an unsubstituted furyl substituent at the 2-position. The compounds exhibit anti-allergy activity and can be used to treat allergic conditions.

Substituted 2-cyclopropylchromones, process of preparation, pharmaceutical compositions and method of treating allergies are disclosed.

Substituted 2-cyclopropyl-chromones and pharmaceutical compositions and

3,4-Dihydro-4-oxo-quinazoline derivatives substituted in the 2-position by a substituted phenyl group are disclosed. The derivatives possess anti-allergy properties and can be used for the treatment of allergic conditions.

2-Disubstituted phenyl-3,4-dihydro-4-oxo-quinazoline derivatives and

6-CARBOXY-FLAVONE DERIVATIVES ARE DISCLOSED, WHEREIN THE FLAVONE DERIVATIVE IS SUBSTITUTED AT THE 2'-POSITION WITH AN ALKOXY GROUP, WHICH MAY BE SUBSTITUTED, AND WHEREIN THE PHENYL RING ALSO CARRIES AN ALKYL SUBSTITUENT. The flavone derivatives exhibit anti-allergic activity and spasmolytic activity.

6-Carboxy-flavone derivatives and process for their preparation

Substituted 2-vinyl-chromones are disclosed wherein the chromone ring has an alkyl or alkenyl substituent at the 3-position. The compounds exhibit anti-allergy activity and can be used to treat allergic conditions.

2-Vinyl-chromones and pharmaceuticals therewith

Chromone compounds carrying a pyridyl substituent at the 2-position are disclosed, such as, for instance, 6-carboxy-2-(2'-pyridyl)-chromone. The disclosed compounds are useful in the treatment of allergies.

5:6-Benzo-.gamma.-pyrone derivatives and process for their preparation

Cyclic derivatives of 1,4-benzoxazine and 1,4-benzothiazine are disclosd, such as, for instance, 1H,2,3,3a,4-tetrahydro-2-carbamoylmethyl-imidazo[5,1-c][1,4]benzoxazin-1-o ne and 1H,2,3,3a,4-tetrahydro-2-carbamoylmethyl-8-chloro-imidazo[5,1-c][1,4]benzo xazin-1-one. These compounds are active on the central nervous system, and function as antidepressant agents.

Imidazo[5,1-c][1,4]benzoxazin-1-one

Novel N-tricyclic derivatives of azetidine are disclosed of the general formula ##STR1## where A is a C.sub.1 -C.sub.3 alkylene group, a C.sub.2 -C.sub.3 alkenylene group or a cyclopropylene group, the remaining substituents being defined in the specification. Such compounds are useful for their anti-depressant, anti-convulsant and anxiolytic activities. The compound 1-[5-(10, 11-dihydro-5H-dibenzo [a,d]cyclopheptenyl)]-3-methyl-amino-azetidine is illustrative.

N-tricyclic derivatives of azetidine and process for their preparation

Chromone compounds carrying a pyrazinyl substituent at the 2-position are disclosed, such as, for instance, 6-carboxy-2-(2'-pyrazinyl)-chromone. The disclosed compounds are useful in the treatment of allergies.

6-Carboxy-2-(2'-pyrazinyl)-chromones and esters thereof

A pharmaceutical composition, and method of treating allergic conditions therewith, is disclosed, wherein said composition contains a 5:6-benzo-.gamma.-pyrone derivative, such as, for instance, 6-carboxy-2'-isopropoxy-flavone. The composition may be used to treat various allergic conditions, including bronchial asthma, allergic rhinitis, hay fever, urticaria and dermatosis.

Pharmaceutical composition containing 5:6-benzo-alpha-pyrone derivatives

Novel N-tricyclic derivatives of azetidine of the formula: ##STR1## wherein A is a --CH.sub.2 --O-- or an --O--CH.sub.2 group, and the remaining substituents being defined in the specification are disclosed. An illustrative compound is 1-[11-(6,11-dihydro-dibenzo [b,e] oxepinyl)]-3-methylamino-azetidine. The compounds are useful for their anti-depressant, anti-convulsant and anxiolytic activities.

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Milan, Italy

Francesco Lauria