Stmicroelectronics S.r.l.

Francesco Ferrara

Marco Angelo Bianchessi

Davide Cucchi

Lorenzo Bruno

Alessandro Paolo Bramanti

Nadia Serina

Lillo Raia

Alessandro Cocci

Marco Cereda

Danilo Pirola

Pietro Ferrari

Marco Pugliese

Pier Paolo Pompa

Ross Rinaldi

The valve is formed in a valve body housing a first path portion, a second path portion, and an coupling zone between the first and second path portions. A shutter is arranged in the coupling zone and has a shutting portion of ferromagnetic material that is deformable under the action of an external magnetic field between an undeformed position, wherein the shutter closes the coupling zone, and a deformed position, wherein the shutter at least partially frees the coupling zone. The shutting portion of the shutter is formed by a rubber membrane incorporating particles, for example of ferrite particles.

Magnetically controllable valve and portable microfluidic device having a magnetically controllable valve, in particular cartridge for sample preparation and molecule analysis

A sample treatment and molecule analysis cartridge is configured to be mounted in a treatment machine vertically. The cartridge has a sample inlet opening, a fluidic inlet, and a fluidic outlet. The cartridge houses an extraction chamber extending vertically from the sample inlet opening and connected to the fluidic inlet; a waste chamber extending vertically, alongside the extraction chamber; and a collector extending along the extraction chamber and the waste chamber and having a smaller height than the extraction chamber and the waste chamber. A fluidic circuit connects together the extraction chamber, the waste chamber, the collector, the fluidic inlet, and the fluidic outlet, and is configured to connect the fluidic outlet to vent openings of the extraction chamber, the waste chamber, and the collector, and to connect the bottom end of the extraction chamber to the fluidic inlet, the waste chamber, and the collector.

Cartridge for sample preparation and molecule analysis, cartridge control machine, sample preparation system and method using the cartridge

A microfluidic valve includes: a first structural layer and a second structural layer; a microfluidic circuit having a first microfluidic conduit and a second microfluidic conduit, which are defined in a superficial portion of the first structural layer, are adjacent, and are separated by a wall; a membrane set between the first structural layer and the second structural layer and delimiting the microfluidic circuit on one side; and a recess containing a gaseous fluid in the second structural layer. The membrane is movable in response to an actuation stimulus between a closed position, in which the first and second microfluidic conduits are fluidly decoupled, and an open position, in which the membrane is at least in part retracted into the recess and the first and second microfluidic conduits are fluidly coupled by means of a fluidic passage defined between the wall and the membrane.

Membrane microfluidic valve and process for manufacturing a membrane microfluidic valve

An apparatus for nucleic acid sequencing includes: a base-detection device in a detection site, the base-detection device being configured to detect bases of a portion of a nucleic acid strand at the detection site; and a conveying device, configured to extend the nucleic acid strand and to cause the extended nucleic acid strand to slide through the detection site along a path. The base-detection device includes a plurality of field-effect nanowire detectors, arranged along the path and each including a respective nanowire and nucleic acid probes, which are defined by respective base sequences and are fixed to the respective nanowire.

Apparatus and method for nucleic acid sequencing based on nanowire detectors

An apparatus for nucleic acid sequencing includes a nanochannel and a conveying device, configured to move a nucleic acid strand through the nanochannel. The conveying device includes: a first electrode, a second electrode, and a third electrode, which are arranged along the nanochannel so as to be in contact with a fluid occupying the nanochannel, the second electrode being arranged between the first electrode and the third electrode; and a control unit configured to apply a first voltage, a second voltage, and a third voltage, respectively, to the first electrode, the second electrode and the third electrode, for controlling movement of the nucleic acid strand through the nanochannel.

Apparatus and method for nucleic acid sequencing based on nanochannels

A chip for nucleic acid analysis includes a body (), in which a detection chamber () is formed for accommodating nucleic acid probes (). A waveguide () is integrated in the body () is and is arranged at the bottom of the detection chamber () so that an evanescent wave (EW), produced at an interface () of the waveguide () when a light radiation is conveyed within the waveguide (), is irradiated towards the inside of the detection chamber (). An apparatus for inspection of nucleic acid probes includes: a holder (), on which a chip () for nucleic acid analysis is loaded, the chip containing nucleic acid probes (); a light source () for supplying an excitation radiation to the nucleic acid probes ('); and an optical sensor () arranged so as to receive radiation coming from the nucleic acid probes ().

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Monteroni di Lecce, Italy

Francesco Ferrara