Provincia Italiana Della Congregazione Dei Figli Dell'immacolata Concezione—instituto Dermopatico Dell'immacolata

Provincia Italiana Della Congregzaione Dei Figli Dell'immacolata Concezione - Istituto Dermopatico Dell'immacolata

Provincia Italiana Della Congregazione Dei Figli Dell'immacolata Concezione-istituto Dermopatico Dell'immacolata

Francesco Facchiano

Antonio Facchiano

Angelo Facchiano

Ivan Rossi

Rita Casadio

A novel peptide, derived from the human fibroblast growth factor (bFGF), is identified. The molecule is able to inhibit in vitro the effects of Platelet Derived Growth Factor (PDGF-BB) and basic Fibroblast Growth Factor (bFGF) on primary rat smooth muscle cells (RASMC) and primary bovine endothelial cells (BAEC) The molecule is also able to inhibit in vivo angiogenesis CD1 mice.

Peptide inhibiting platelet derived growth factor (PDGF-BB) and fibroblast growth factor (bFGF) activity

Novel molecules without intramolecular peptidic bonds, able to mimic the RGD peptide, containing ARG-GLY-ASP motif &ldquo;arginine-glycine-aspartic acid&rdquo; (that is a potent inhibitor, in vivo and in vitro, of cellular adhesion) In vitro experimentation demonstrated that said molecules are efficient inhibitors of RASMC adhesion, proliferation and migration.

RGD-analog non-peptidic molecules having anti-adhesive, anti-migration and anti-proliferative effects

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Rome, Italy

Francesco Facchiano