Boston Scientific Scimed, Inc.

Biocompatibles UK Limited

Francesco Cuda

Yiqing Tang

Andrew Lennard Lewis

Sean Leo Willis

Koorosh Ashrafi

Hugh Britton

Cristian Parisi

Nicolas Van Luc Busatto

Andrew L Lewis

Sean L Willis

In various embodiments, the present disclosure pertains to compositions for medical use. In some embodiments, the compositions comprise an aqueous solution of a block copolymer that comprises one or more poly(N-isopropylamino acrylamide) blocks and one or more poly(2-(di-(C)alkylamino) (C)alkyl methacrylate) blocks. In some embodiments, the compositions are in liquid form at 25° C. Other embodiments pertain to methods that comprise delivering such compositions to a patient.

Stimuli responsive block copolymers

The present disclosure relates to radiopaque PVA polymers where the PVA has a first pendant group and a second pendant group, wherein the first pendant group comprises a first phenyl group bearing 1 to 5 iodine atoms, and the second pendant group comprises either (a) a second phenyl group bearing 1 to 3 substituents selected from the group W and optionally 1 to 4 iodine substituents, the group(s) W and the optional iodines being the sole substituents of the second phenyl group. Each W is selected from &#x2014;OH, &#x2014;COOH, &#x2014;SOH, &#x2014;OPOH, &#x2014;O&#x2014;(Calkyl), &#x2014;O&#x2014;(Calkyl)OH, &#x2014;O&#x2014;(Calkyl)R, &#x2014;O&#x2014;(CHO)R&#x2014;(C&#x2550;O)&#x2014;O&#x2014;Calkyl and &#x2014;O&#x2014;(C&#x2550;O)Calkyl; wherein Ris H or Calkyl; Ris &#x2014;COOH, &#x2014;SOH, or &#x2014;OPOH; q is an integer from 1 to 4; wherein the group W may be in the form of a pharmaceutically acceptable salt; or (b) a pyridyl group; which is optionally in the form of a pyridinium ion.

Radiopaque polymers

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Basingstoke, United Kingdom

Francesco Cuda