Glaxosmithkline Biologicals Sa

Novartis Vaccines and Diagnostics Srl

J. Craig Venter Institute

J. Craig Venture Institute, Inc.

Francesco Berlanda Scorza

Mariagrazia Pizza

Maria Rita Fontana

Laura Serino

Danilo Gomes Moriel

Vega Masignani

Herve Tettelin

Nathalie Norais

Andrew John Geall

Allan James Saul

Yingxia Wen

Christiane Gerke

Frederick Porter

Luana Maggiore

Hyperblebbingstrains are generated by disrupting one or more components of the Tol-Pal system. The blebs from these strains are useful immunogens for vaccination. The individual proteins found in these blebs can also be used as immunogens.

Hyperblebbingstrains

Methods for purifying RNA from a sample, comprising one or more steps of tangential flow filtration, hydroxyapatite chromatography, core bead flow-through chromatography, or any combinations thereof. These techniques are useful individually, but show very high efficiency when used in combination, or when performed in particular orders. The methods can purify RNA in a highly efficient manner without unduly compromising potency or stability, to provide compositions in which RNA is substantially cleared of contaminants. Moreover, they can be performed without the need for organic solvents.

RNA purification methods

Disclosed herein are various open reading frames from a strain ofresponsible for neonatal meningitis (MNEC), and a subset of these that is of particular interest for preparing compositions for immunizing against MNEC infections.

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Disclosed herein are various open reading frames from a strain ofresponsible for neonatal meningitis (MNEC), and a subset of these that is of particular interest for preparing compositions for immunising against MNEC infections.

Disclosed herein are various genes that can be included in immunogenic compositions specific for pathogenicstrains. The genes are from uropathogenic strains but are absent from non-pathogenic strains, and their encoded proteins have cellular locations which render them accessible to the immune system.

Growing community of inventors

Trento, Italy

Francesco Berlanda Scorza