Nestec S.a.

Francesca Stingele

Jean-Richard Neeser

Beat Mollet

Bernhard Guggenheim

Pier Sandro Cocconcelli

Elena-Maria Comelli

David Pridmore

Walter Gaier

Bruno Pot

Patrice Desachy

A lactic bacteria strain that is exogenous to the oral microflora is selected for its ability to adhere the pellicle of the teeth and to produce a growth inhibition factor. This strain is used for the preparation of a composition intended for reducing dental plaque and for treating or preventing root caries and other diseases related toin mammals.

Treatment of actinomyces naeslundii-related diseases with exogenous lactic bacteria strains

The present invention provides compositions for the prophylaxis or treatment of dental caries, dental plaque, and periodontal infection that include lactic bacteria that are not part of the resident micriflora of the mouth, that are low acidifying, and that are capable of adhering directly to the pellicle of the teeth. Preferably, the lactic bacteria of the include one or more ofsubsp.orsubsp.The compositions are used in methods of treating or preventing dental caries, dental plaque, and periodontal infection.

Incorporation of exogenous lactic bacteria into the oral microflora

Strain of lactic acid bacterium, (1) whose 16S ribosomal RNA is characteristic of the genus Streptococcus, (2) whose total protein profile, obtained after migration of the total proteins on an SDS-PAGE electrophoresis gel, is characteristic of that of the strain of lactic acid bacterium CNCM I-1920 but distinct from those of the recognized species belonging to the genus Streptococcus, namely ssp. ssp. ssp. ssp. . The invention also relates to the use of a strain of lactic acid bacterium according to the invention, or of a polysaccharide secreted by a strain according to the invention, for the preparation of a dietary composition, in particular an acidified milk or a fromage frais. The invention also relates to a dietary or pharmaceutical composition comprising a strain of lactic acid bacterium or a polysaccharide consisting of a succession of glucose, galactose and N-acetylglucosamine in a respective proportion of 3:2:1. In particular, strains CNCM I-1920, I-1921, I-1922, I-1923, I-1924, I-1925 and I-1926.

Lactic acid bacteria species

DNA fragment of genomic origin coding for at least one enzyme involved in the biosynthesis of an EPS, and capable, following the transformation of a lactic bacteria, of restoring the production of an EPS in the said bacterium not initially producing any EPS, or of modifying the structure of the EPS initially produced by the said bacterium. Proteins of the Streptococcus thermophilus strain CNCM I-1590 encoded by the chromosome and which are involved in the biosynthesis of the EPS having the composition Glc:Gal:GalNac=1:2:1. Method for the manufacture of a new EPS, in which a DNA fragment coding partially or totally for at least one enzyme involved in the biosynthesis of an EPS is cloned into a vector, lactic bacteria producing another EPS are transformed with the recombinant vector, and a lactic bacterium producing a new EPS is then selected.

Growing community of inventors

St-Prex, Switzerland

Francesca Stingele