Ucl Business Plc

Francesca Cordeiro

Stephen Moss

Katy Coxon

James Duggan

Frederick Fitzke

Benjamin Michael Davis

Satyanarayana Somavarapu

Ljuban Grgic

A pharmaceutical composition is provided comprising a vitamin E derivative, an anionic phopholipid-binding protein, an anionic phospholipid and a sterol. Also provided is a method for preparing a composition for delivering a cargo to a subject comprising a) forming liposomes from a vitamin E derivative, an anionic phospholipid-binding protein such as annexin, an anionic phospholipid such as phosphatidylserine and a sterol; and b) encapsulating the cargo in the liposomal composition.

Carrier comprising a vitamin E derivative

The invention relates to a carrier for delivering agents to the posterior region of the eye, the carrier comprising a Vitamin E derivative, especially tocopherol. The carrier may also comprise a cell death marker, such as an annexin.

Pharmaceutical composition comprising a Vitamin E derivative and a cell death marker

The invention relates to the use of a cell death marker labelled with a wavelength-optimised label for identifying cell death in the eye. Suitable cell death markers are the Annexins and fragments and derivatives thereof. The invention also relates to a pharmaceutical composition comprising a cell death marker labelled with a wavelength-optimised label and a method for monitoring cell death in the eye using a cell death marker labelled with a wavelength-optimised label.

Composition comprising a cell death marker and a wavelength-optimized label

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London, United Kingdom

Francesca Cordeiro