The General Hospital Corporation

Aalborg University

Francesca Bersani

Daniel Arie Haber

Shyamala Maheswaran

Anders M Naar

David T Ting

Andreas Petri

Sakari Kauppinen

Mihir Shivadatta Rajurkar

Methods for treating cancer, e.g., cancer of epithelial origin, by specifically targeting human satellite II (HSATII) using sequence specific agents such as oligonucleotides.

Targeting human satellite II (HSATII)

Methods for treating cancer, e.g., cancer of epithelial origin, by specifically targeting human satellite II (HSATII) using sequence specific agents such as oligonucleotides. As shown herein, the hetero chromatic HSATII satellite repeat is silenced in normal cells, but massively over expressed in epithelial cancers and in cancer cell lines when grown as xenografts or in 3D culture. Induction of HSATII RNA, either in xenografts or using in vitro reconstitution models, suggests the appearance of complementary DNA intermediates.

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Turin, Italy

Francesca Bersani