Nicox S.a.

Italfarmaco Spa

Nicox Science Ireland

Ferrer Internacional, S.a.

Francesca Benedini

Piero Del Soldato

Ennio Ongini

Valerio Chiroli

Stefano Biondi

Alberto Sala

Patrizia Antognazza

Roberta Cereda

Graziano Castaldi

Erminio Oldani

Wesley Kwan Mung Chong

Giancarlo Santus

Laura Storoni

Aldo Banfi

Silvio Levi

Antonio Tarquini

Gael Ronsin

Annalisa Bonfanti

Rebecca Steele

Gabriele Razzetti

Giangiacomo Torri

Benito Casu

Antonio Guglietta

Achim Hans-Peter Krauss

Giorgio Bertolini

Annamaria Naggi

Yi Yang

Gianni Gromo

William Vernier

Liming Dong

Francesco Impagnatiello

Michael Niesman

Ganesh Prasanna

Fabio Nicoli

Roberto Barani

Giancarlo Dona

Marta Princep

Piero Soldato

Sala Alberto

Simona Venturini

Paolo Gresele

Eninnio Ongini

Wesley Kwan Chong

William Francois Vernier

Achim Hans-Pter Krauss

Daniel Palop

The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.

Quinone based nitric oxide donating compounds

The invention relates to nitrooxy derivatives of fluocinolone acetonide, triamcinolone acetonide, betamethasone and beclomethasone, methods for their preparation, pharmaceutical compositions containing these compounds, and methods of using these compounds and compositions for treating diabetic macular edema, diabetic retinopathy, macular degeneration, age-related macular degeneration and other diseases of retina and macula lutea.

Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology

The invention relates to nitrooxyderivative of corticosteroids of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereofR&#x2014;(Z)&#x2014;R&#x2003;&#x2003;(I)wherein R is the corticosteroid residue of formula (II): wherein:  The compounds are useful in the treatment of respiratory diseases, inflammatory diseases, dermatological diseases and ocular diseases.

Nitric oxide releasing steroids

Nitroderivatives of prostaglandins having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.

Nitric oxide donating prostamides

Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.

Prostaglandin derivatives

The present invention relates to &#x3b2;-adrenergic blockers nitrooxyderivatives of general formula (I):A-(Y&#x2014;ONO)and enantiomers and diastereoisomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them and their use for the treatment of hypertension, cardiovascular diseases, glaucoma, migraine headache and vascular diseases.

Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive

The present invention relates to alpha2-adrenergic receptor agonist nitrooxyderivatives, including the following structure, having improved pharmacological activity and enhanced tolerability. They can be employed for the treatment of ocular diseases, in particular high intraocular pressure and glaucoma.

Quinoxaline derivatives of alpha-2 adrenergic agonists

The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of a drug and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independently an integer from 0 to 6, and p is 0 or 1, and X is O, S, SO, SO2, NR13 or PR13 or an aryl, heteroaryl group, said process comprising reacting a compound of formula (B) R&#x2014;COOZ (B) wherein R is as defined above and Z is hydrogen or a cation selected from: Li+, Na+, K+, Ca++, Mg++, tetralkylammonium, tetralkylphosphonium, with a compound of formula (C), as reported in the description, wherein R1-R12 and m, n, o, p, q, r, s are as defined above and Y is a suitable leaving group.

Process for preparing nitrooxyalkyl substituted esters of carboxylic acids, intermediates useful in said process and preparation thereof

Nitroderivatives of prostaglandin amides having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.

Use for the treatment of diseases having an inflammatory basis of compounds or salts thereof, Having the following general formula (I): A&#x2014;X&#x2014;L&#x2014;(W)&#x2014;NOwherein A contains the radical of a drug, Xand W are bivalent radicals, L is a covalent bond or oxygen, sulphur, NRwherein Ris H or a C-Clinear or branched alkyl.

Nitroderivatives as drugs for diseases having an inflammatory basis

Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.

Statin derivatives

Growing community of inventors

Milan, Italy

Francesca Benedini