Corning Incorporated

Frances M Smith

Edward John Fewkes

Dana Craig Bookbinder

David Lambie Tennent

James Arthur Griffin, Jr

Marie D Bryhan

Leroy S Hersh

Robert Michael Morena

Ronald E Johnson

William Allen Wood

Mark Stephen Friske

Jean-Pierre Themont

Candace J Quinn

Lung-Ming Wu

Bernard Eid

Margaret E Greene

Alain Re Carre

Rachel S Mozdy

Atul D Pradhan

Atul Deep Pradhan

Edward J Fewkes Jr

James A Griffin

Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cmare achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 to the surface; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to the mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.

Method for making a polymer blend for reducing protein binding to surfaces

Method for reducing loss of enzyme activity during storage

Method for reducing binding of organic material to hydrophobic surfaces

An optical waveguide fiber amplifier comprising a core region comprises at least in part between 1300 wt.ppm and 3600 wt.ppm Er O , between 6.0 wt. % to 10.0 wt. % Al O and between 9.0 wt. % and 20.0 wt. % GeO . The amplifier also comprising an inner clad surrounding the core region and an outer clad surrounding the inner clad. The relative refractive index percentages and radii of the core region, inner clad and outer clad are chosen from the following ranges: the relative refractive index percent of the core segment within the range of from about 0.5% to about 2.0%; the relative refractive index percent of the inner clad within the range of from about 0.0% to about 0.4%; the outer radius of the core region within the range of from about 0.7 &mgr;m to about 1.5 &mgr;m; and, the outer radius of the inner clad within the range of from about 4.3 &mgr;m to about 18.8 &mgr;m.

High absorption erbium doped amplifying optical fiber

Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 to the surface; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions. Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to the mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.

Methods for producing low binding surfaces

Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm,are achieved by: (1) applying to a hydrophobic polymer surface a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 and at least one hydrophilic element which can extend into an aqueous solution; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions. Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article. Molding uses shear condition that cause the surfactant to move to the surface of a polymer product formed by the molding such that a hydrophilic part of the surfactant extends from the surface to provide a surface having low binding for proteins.

Low protein-binding polymer product produced using low HLB number non-ionic surfactant

Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm.sup.2 are achieved by: (1) applying to a hydrophobic polymer surface a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 and at least one hydrophilic element which can extend into an aqueous solution; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions. Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.

Producing low binding hydrophobic surfaces by treating with a low HLB

Sealing glass paste method

A method of producing a formable mixture involves combining a powder material, and a plurality of gel-forming polymers, wherein at least one gel-forming polymer is a proton donor, and at least one gel forming polymer is a proton acceptor. A method of making a monolithic structure involves producing a formable mixture of powder material which can be ceramic, metal, glass, glass ceramic, molecular sieve and combinations thereof, a plurality of gel-forming polymers as described above, extruding the mixture to form a green monolithic structure, and drying and firing the green structure.

Rapid-setting formable mixtures and method of making and using same

A method and apparatus for making formed glass structures. A glass frit containing material is deposited within a recessed pattern, hardened in the recessed pattern, and transferred to a substrate. The method and apparatus of the invention are particularly useful for forming barrier rib structures for use in plasma display panels.

Method for forming glass rib structures

A method of attaching dialdehyde starch to surfaces is disclosed. A substrate to which substances may be coupled, which substrate comprises at least one surface coated with dialdehyde starch, and products produced utilizing the substrate are also provided.

Method of attaching dialdehyde starch to a surface and products produced

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Elmira, NY, United States of America

Frances M Smith