Emory University

Microbplex, Inc.

Frances Eun-Hyung Lee

Ignacio Sanz

Doan Nguyen

John L Daiss

This disclosure relates to growth media and environments for in vitro culturing of cells that produce or are capable of producing antibodies. In certain embodiments, the media comprises IL-6, fibronectin, and typically a saccharide. In certain embodiments, the disclosure contemplates cell culture compositions comprising IL-6 and fibronectin that are derived from proteins secreted from mesenchymal stromal/stem cells (MSCs). In certain embodiments, the disclosure contemplates enclosures comprising culture compositions disclosed herein that are in ambient air or optionally in an environment wherein oxygen is absent or at a low concentration.

Growth and survival compositions for cells capable of producing antibodies and methods related thereto

This disclosure relates to methods of culturing and characterizing antibody secreting cells. In certain embodiments, this disclosure relates to methods of isolating antibody secreting cells, e.g., long lived plasma cells, replicating the isolated cells in growth media disclosed herein, and determining the nucleic acids sequences in the cells that encode the produced antibodies.

Methods of culturing and characterizing antibody secreting cells

Disclosed are methods and kits for early detection of antigen exposure through the presence or absence of antigen-specific antibodies.

Growing community of inventors

Atlanta, GA, United States of America

Frances Eun-Hyung Lee