Hoffmann-La Roche Inc.

Francedillaois Jenck

Geo Adam

Andrea Cesura

Stephan Rover

Jurgen Wichmann

Guido Galley

Sabine Kolczewski

Caido Galley

Frederick Monsma, Jr

The present invention relates to compounds of the formula ##STR1## wherein X is --O-- or --CH.sub.2 --;

Piperidine derivatives

The invention relates to compounds of the general formula ##STR1## wherein R.sup.1 is C.sub.6-12 -cycloalkyl, optionally substituted by lower alkyl or C(O)O lower alkyl, indan-1-yl or indan-2-yl, optionally substituted by lower alkyl; acenaphthen-1-yl; bicyclo[3.3.1]non-9-yl, octahydro-inden-2-yl; 2,3-dihydro-1H-phenalen-1-yl; 2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl, decahydro-azulen-2-yl; bicyclo[6.2.0]dec-9-yl; decahydro-naphthalen-1-yl, decahydro-naphthalen-2-yl; tetrahydro-naphthalen-1-yl, tetrahydro-naphthalen-2-yl or 2-oxo-1,2-diphenyl-ethyl;

Diaza-spiro[3,5] nonane derivatives

The present invention relates to compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are each independently hydrogen, lower alkyl, lower alkoxy or halogen;

1,3,8-triazaspiro[4,5]decan-4-one derivatives

The present invention relates to compounds of formula I and pharmaceutically acceptable acid addition salts thereof.

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Riedisheim, France

Francedillaois Jenck