City of Hope

Fouad Kandeel

Sanjay Awasthi

Sharad S Singhal

Sushma Yadav

Ismail Al Abdullah

Brian McFadden

Indu Nair

Qiang Liu

Yun Yen

Steve S Sommer

Kevin Ferreri

Rasha Shehatta

The present disclosure provides novel methods for increasing &#x3b2;-cell viability in islets by delivering RLIP76 polypeptides or GSTA4 polypeptides, or a combination thereof; or RLIP76 polynucleotides or GSTA4 polynucleotides, or a combination thereof, to the islets. The disclosure also provides novel methods for treating a disease or condition in a subject, such as type 1 diabetes mellitus, by delivering RLIP76 polypeptides or GSTA4 polypeptides, or a combination thereof; or RLIP76 polynucleotides or GSTA4 polynucleotides, or a combination thereof, to islets and transplanting the islets into the subject to treat the disease or condition. Kits and compositions including RLIP76 polypeptides or GSTA4 polypeptides, or a combination thereof; or RLIP76 polynucleotides or GSTA4 polynucleotides, or a combination thereof, are also provided to increase &#x3b2;-cell viability.

Methods, compositions, and kits for improving pancreatic beta cell viability and treating diseases or conditions related to beta cell destruction

The present invention provides a method for detecting transplantation failure of a transplanted organ or cells which comprises detecting a donor-positive but recipient-negative DNA marker in the recipient's plasma using pyrophosphorolysis activated polymerization. Because of the high sensitivity, specificity and selectivity of pyrophosphorolysis activated polymerization, transplantation failure can be detected at early stages and treatment can be initiate earlier.

Ultra-high sensitive monitoring of early transplantation failure

Growing community of inventors

Duarte, CA, United States of America

Fouad Kandeel