Institut Pasteur

Fotini Betsou

Peter Sebo

Nicole Guiso

Nicole Gutso

Purified nucleic acids comprising a nucleotide sequence encoding an immunogenic polypeptide of adenyl cyclase-haemolysin (AC-Hly), which induces formation of protective antibodies against an infection by a bacteria selected from the group consisting of, andwhen the nucleic acid or polypeptide is administered to a human or animal host. The nucleic acids are useful, for example, to induce a protective immune response in a host against infection by a bacteria selected from the group consisting of, and

Nucleic acids encoding protective epitopes of adenyl cyclase-haemolysin (AC-Hly)

The subject of the invention is amino acid sequences of the AC-Hly fromand/or, carrying epitopes capable of inducing a protective immune response against infection by. The subject of the invention is antibodies, especially monoclonal antibodies, directed against these epitopes.

Protective epitopes of adenyl cyclase-haemolysin (AC-Hly), their application to the treatment or to the prevention of bordetella infections

The subject of the invention is amino acid sequences of the AC-Hly from,and/or,carrying epitopes capable of inducing a protective immune response against infection by Bordetella. The subject of the invention is antibodies, especially monoclonal antibodies, directed against these epitopes.

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Paris, France

Fotini Betsou