G.d. Searle & Company

Pharmacia Corporation

Fortunato Vanzanella

John S Ng

Bernhard Erb

Ping T Wang

Yuen-Lung L Sing

Leo J Letendre

Joseph J Wieczorek

Mark John Pozzo

Edward E Yonan

Chin Liu

Jon P Lawson

Dennis K Anderson

Sastry A Kunda

Julio A Baez

Gennaro Mucciariello

Multiple novel keto-substituted intermediates are provided for the synthesis of epoxymexrenone, useful as an Aldosterone Receptor Antagonist.

Keto-substituted steroid compounds

Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula Iwherein:

Process for preparation of 9, 11-epoxy steroids and intermediates useful therein

Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula Iwherein: &#x2014;A&#x2014;A&#x2014;, &#x2014;B&#x2014;B&#x2014;, R, R, Rand Rare as defined in the specification.

Processes for preparation of 9,11-epoxy steroids and intermediates useful therein

Process for preparation of 9,11-epoxy steroids and intermediates useful therein

A process for the formation of an epoxy compound comprising contacting a substrate compound having an olefinic double bond with a peroxide compound in the presence of a peroxide activator, said peroxide activator corresponding to the formula:

Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein

Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone, useful as a diuretic, and other compounds of Formula I

Keto-Substituted Steroid Compounds

Multiple reaction schemes, process steps and intermediates are provided for the synthesis of epoxymexrenone, useful as a diuretic, and other compounds of Formula I

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Naples, Italy

Fortunato Vanzanella