Tokitae LLC

University of Washington

Fong-Li Chou

Shieng Liu

Nels R Peterson

Lowell L Wood, Jr

Fridrik Larusson

Philip Andrew Eckhoff

Lawrence Morgan Fowler

Brian L Pal

Jennifer Ezu Hu

Jae-Hyun Chung

Kyong-Hoon Lee

Clarence T Tegreene

Nathan P Myhrvold

William Henry Gates, Iii

David J Yager

Daniel M Ratner

Woonhong Yeo

Krishnan Natarajan

Gareth Fotouhi

Jeffrey W Chamberlain

Muriel Y Ishikawa

Victoria Y H Wood

Roderick A Hyde

Edward K Y Jung

Charles Whitmer

Geoffrey Frank Deane

Peter K Maier-Laxhuber

Dayong Gao

Kie Seok Oh

Maurizio Vecchione

Roderick T Hinman

Zihong Guo

Ozgur Emek Yildirim

Ralf W Schmidt

Matthew W Peters

David Joseph Gasperino

Michael Friend

David Keith Piech

Ryan Calderon

Shannon Weise Stone

Matthew F Rosen

Kieseok Oh

Woon-Hong Yeo

John Boomgard

William Gates

Victoria Yh Wood

Philip Andrew Welkhoff

Reinier M WÖRZ

In some embodiments, an affixed group of pharmaceutical vials with frangible connectors includes: a plurality of pharmaceutical vials arranged as a group of pharmaceutical vials, each of the plurality of pharmaceutical vials shaped and positioned to minimize a total volume of the group of pharmaceutical vials, each of the pharmaceutical vials including at least one external side with a surface configured to reversibly mate with a corresponding external side and a surface of an adjacent pharmaceutical vial; and a plurality of frangible connectors, wherein at least one frangible connector is affixed to the surface of at least two of the plurality of pharmaceutical vials within the group of pharmaceutical vials, and at least one frangible connector is affixed to each of the plurality of pharmaceutical vials.

Affixed groups of pharmaceutical vials including frangible connectors

In some embodiments, a medicinal carrier device includes: one or more sections of thermal insulation positioned to form an internal space with an adjacent first side region and an adjacent second side region; a first panel including a first phase change material positioned within the first side region of the internal space, the first side region of a size and shape to firmly contain an integral number of portable cold packs in thermal contact with the first panel; and a second panel including a second phase change material positioned within the second side region of the internal space, the second side region of a size and shape to firmly contain an integral number of portable cold packs in thermal contact with the second panel.

Freeze-free medicinal transport carriers

Generally, this disclosure relates to methods of prioritizing or directing available power to a main device, such as a temperature-stabilized and/or temperature-controlled storage container. In an embodiment, the method may include measuring electrical power available from a solar photovoltaic module array that is electrically coupled to the main device, and modulating the electrical power drawn by the main device based on the available electrical power. Available power unused by the main device may be diverted to one or more secondary devices.

Directing or modulating electrical power drawn by one or more loads from a solar photovoltaic module array while maintaining a buffer margin

A refrigeration device includes a thermal transfer unit with an evaporative region, an adiabatic region, and a condensing region with a reversible valve attached to the adiabatic region. The device includes a container sealed around PCM, with a set of refrigeration coils of a compressor unit in thermal contact with the PCM. A storage region is in thermal contact with the evaporative region of the thermal transfer unit. A controller is operably connected to the reversible valve and the refrigeration compressor unit. The storage region can be used to store cold packs within a predetermined temperature range for medical outreach.

Devices for use with refrigeration devices including temperature-controlled container systems

Multi-monodose containers are described including a row of at least two vials, a first vial connected to an adjacent second vial through an articulating joint, the articulating joint sufficiently flexible to reversibly mate a planar outer surface of the first vial with a planar outer surface of the adjacent second vial; wherein the row of the at least two vials is configured to form a first rectangular packing cross-sectional area in an expanded configuration and configured to form a second rectangular packing cross-sectional area in a folded configuration, the second rectangular packing cross-sectional area smaller than the first rectangular packing cross-sectional area.

Multi-monodose containers

Disclosed embodiments include portable devices for cold chain storage and methods of fabricating portable devices for cold chain storage. In an illustrative embodiment, a portable device for cold chain storage includes a container defining therein a storage region. The container includes an inner cylinder, and the storage region is defined coaxially inwardly of the inner cylinder. The inner cylinder includes phase change material disposed therein, and the phase change material is in thermal communication with the storage region. The inner cylinder also includes evaporative coils disposed therein. The evaporative coils are embedded in the phase change material. The container also includes a thermally insulated outer cylinder. An outer wall of the outer cylinder is disposed radially outwardly of an outer wall of the inner cylinder.

Portable device for cold chain storage

In some embodiments, a thermosiphon configured for use within a temperature-regulated storage device includes: a condenser region, including a plurality of evenly spaced condenser channels with horizontally symmetrical bifurcated branches connected to an adiabatic channel, each of the plurality of condenser channels connected at a top position to an upper channel; an evaporator region, including a plurality of evaporator channels, wherein each of the plurality of evaporator channels has a flow channel formed in a serpentine channel pattern and each subunit of the serpentine channel pattern is attached to a vapor return channel at a top of the subunit, and wherein the evaporator region has at least one lowest position connected directly to a vapor return channel; and an adiabatic region including at least one adiabatic channel connecting the evaporator channels and the condenser channels.

Thermosiphons for use with temperature-regulated storage devices

Methods are described for packaging a foldable container including covering a multi-monodose container in an expanded configuration with a hermetically-sealable overwrap, the multi-monodose container including a row of interconnected monodose pharmaceutical vials, each of the monodose pharmaceutical vials enclosing at least one pharmaceutical agent, the interconnected monodose pharmaceutical vials connected to one another by one or more articulating joints sufficiently flexible to form a folded configuration of the multi-monodose container; exerting a force on at least one of the monodose pharmaceutical vials; bending the one or more articulating joints to form the folded configuration of the multi-monodose container in response to the exerted force; and sealing the hermetically-sealable overwrap to form a hermetic seal around the folded configuration of the multi-monodose container.

Method of packaging multi-monodose containers

In some embodiments, a refrigeration device includes: walls substantially forming a liquid-impermeable container configured to hold phase change material internal to the refrigeration device; at least one active refrigeration unit including a set of evaporator coils positioned at least partially within the liquid-impermeable container; a unidirectional thermal conductor with a condensing end and an evaporative end, the condensing end positioned within the liquid-impermeable container; a first aperture in the liquid-impermeable container, the first aperture of a size, shape and position to permit the set of evaporator coils to traverse the aperture; a second aperture in the liquid-impermeable container, the second aperture including an internal surface of a size, shape and position to mate with an external surface of the unidirectional thermal conductor; and one or more walls substantially forming a storage region in thermal contact with the evaporative end of the unidirectional thermal conductor.

Refrigeration devices including temperature-controlled container systems

In some embodiments, a medicinal storage container includes: a desiccant unit including external walls forming a gas-impermeable barrier around an interior desiccant region and including an aperture; a heating element; a controller operably attached to the heating element; a cooling unit; a compressor system including at least one evaporator coil unit, the compressor operably connected to the controller; a vapor conduit, the vapor conduit attached to a the desiccant unit at a first end, the vapor conduit attached to the evaporative cooling unit at a second end, the vapor conduit forming an internal, gas-impermeable passageway between the desiccant unit and the cooling unit; a vapor control unit attached to the vapor conduit and operably attached to the controller; and a medicinal storage unit including external walls encircling a medicinal storage region including a temperature sensor operably connected to the controller.

Temperature-controlled medicinal storage devices

In some embodiments, a refrigeration device includes: walls substantially forming a liquid-impermeable container configured to hold phase change material internal to a refrigeration device; at least one active refrigeration unit including a set of evaporator coils positioned within an interior of the liquid-impermeable container; walls substantially forming a storage region; and a heat transfer system including a first group of vapor-impermeable structures with a hollow interior connected to form a condenser in thermal contact with the walls substantially forming a liquid-impermeable container, a second group of vapor-impermeable structures with a hollow interior connected to form an evaporator in thermal contact with the walls substantially forming a storage region, and a connector with a hollow interior affixed to both the condenser and the evaporator, the connector forming a liquid and vapor flow path between the hollow interior of the condenser and the hollow interior of the evaporator.

Methods and systems are provided for concentrating particles (e.g., bacteria, viruses, cells, and nucleic acids) suspended in a liquid. Electric-field-induced forces urge the particles towards a first electrode immersed in the liquid. When the particles are in close proximity to (e.g., in contact with) the first electrode, the electrode is withdrawn from the liquid and capillary forces formed between the withdrawing electrode and the surface of the liquid immobilize the particles on the electrode. Upon withdrawal of the electrode from the liquid, the portion of the electrode previously immersed in the liquid has particles immobilized on its surface.

Particle concentration system

Embodiments disclosed herein relate to apparatuses and methods for storing temperature-sensitive items. More specifically, embodiments include a storage apparatus that may store the temperature-sensitive items. For example, the storage apparatus may include a storage compartment that may be maintained at a predetermined temperature or temperature range.

Storage apparatuses and related methods for storing temperature-sensitive items

Substantially thermally sealed containers including flexible connectors joining an aperture in the exterior of the container to an aperture in a substantially thermally sealed storage region within the container are described. The flexible connectors include a duct forming an elongated thermal pathway between the exterior of the container and the substantially thermally sealed storage region within the container. The flexible connectors include compression units mated to each end of the duct and a plurality of compression strands connected between the compression units.

Temperature-stabilized storage systems with flexible connectors

Method and system for concentrating particles from a solution

Growing community of inventors

Bellevue, WA, United States of America

Fong-Li Chou