Arthrosave Holding B.v.

Synerkine Pharma B.v.

Umc Utrecht Holding B.v.

Floris Paulus Jacobus Gerardus Lafeber

Thijmen Struik

Vincent Marianus Cloostermans

Karianne Hilde Lindenhovius

Cornelis Erik Hack

Simon Carl Mastbergen

Joel Adrianus Gijsbert Van Roon

Christina Louws

Sarita Aimee Yvonne Hartgring

Petrus Maria Van Roermund

Hubertus Paul Maria Ter Braak

Karianne Hide Lindenhovius

An external distractor to gradually enlarge the distance between first and second bone parts includes first and a second connection devices. The first and second connection devices are connected to the first and second bone parts, respectively, with first and second respective bone pins. The distractor includes an adjustment device between the connection devices for adjusting the distance between the connection devices along an adjustment axis. The adjustment device includes a tubular base body coupled to the first connection device, an extension tube coupled to the second connection device and an adjustment mechanism for moving the extension tube with respect to the base body along the adjustment axis. The adjustment mechanism includes a rotatable adjustment ring for moving the extension tube upon rotation of the adjustment ring around the adjustment axis. The adjustment mechanism includes a spring engaging the adjustment ring for preventing unintended activation of the adjustment mechanism.

External distractor and adjustment device for use in such a distractor

System for connecting a connection device to a bone with a bone pin, wherein the connection device is provided with an opening for receiving the bone pin, wherein the system comprises:

System for connecting a connecting device, in particular a distractor, to a bone

System for connecting a connection device to a bone with a bone pin, wherein the system comprises a connection device provided with an opening for receiving the bone pin, and wherein the system further comprises a locking device arranged to be received in the opening of the connection device and which is arranged to engage the bone pin for locking the bone pin with respect to the connection device, wherein the locking device is movable between a locked position, wherein the bone pin is locked with respect to the connection device, and an unlocked position wherein the bone pin is movable with respect the connection device, wherein the system further comprises a blocking mechanism for at least partially blocking the opening in the connection device upon removal of the bone pin from the opening.

System for connecting a connection device to a bone

The invention is concerned with a fusion protein, a nucleic acid molecule encoding such fusion protein, a vector comprising such nucleic acid molecule, and a host cell comprising such nucleic acid molecule or such vector. The invention further pertains to a method for producing such fusion protein. The fusion protein or a gene therapy vector encoding the fusion protein may be used in the prevention or treatment of osteoarthritis, chronic pain, a condition characterized by local or systemic inflammation, immune activation, and/or lymphoproliferation.

Fusion protein comprising IL-4 and IL-10

System for connecting a connection device to a bone with a bone pin, wherein the connection device is provided with an opening for receiving the bone pin, wherein the system comprises: &#x2014;said connection device; &#x2014;a guiding tube arranged to guide the bone pin from the connection device to the bone for connecting the bone pin to the bone, wherein the inner diameter of the guiding tube corresponds to the outer diameter of the bone pin and wherein the guiding tube can be slidably received in the opening, the guiding tube being slidable with respect to the connection device along an axis parallel to a longitudinal axis of the opening; &#x2014;a locking device arranged to be received in the opening of the connection device and arranged to engage the bone pin for locking the bone pin with respect to the connection device, wherein the guiding tube is movable with respect to the connection device and bone pin such that the guiding tube is removable from the combination of the bone pin and the connection device and wherein the locking device is arranged to lock the bone pin after removal of the guiding tube.

The invention is concerned with a fusion protein comprising interleukin 10 and interleukin 4, a nucleic acid molecule encoding such fusion protein, a vector comprising such nucleic acid molecule, and a host cell comprising such nucleic acid molecule or such vector. The invention further pertains to a method for producing such fusion protein. The fusion protein or a gene therapy vector encoding the fusion protein may be used in the prevention or treatment of osteoarthritis, chronic pain, a condition characterized by local or systemic inflammation, immune activation, and/or lymphoproliferation.

Growing community of inventors

Houten, Netherlands

Floris Paulus Jacobus Gerardus Lafeber