Cambridge Enterprise Limited

Florin Tudor Ilca

Andreas Heinrich Neerincx

Louise Helen Boyle

This invention relates to peptide-exchange proteins comprising the luminal domain of TAP-binding protein-related (TAPBPR), which functions as a MHC class I peptide-exchange catalyst when presented to mammalian cells either as a soluble extracellular protein or as a membrane bound cell surface protein. This may be useful in modulating immune responses, including for example loading immunogenic peptide onto tumours or other disease cells to induce their recognition by T cells. Peptide-exchange proteins and methods for their use are provided.

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Cambridgeshire, United Kingdom

Florin Tudor Ilca