University of Utah Research Foundation

Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V.

Sentiomed, Inc.

Florian Solzbacher

Jules J Magda

Richard A Normann

Sandeep Negi

Navid Farhoudi

Christopher F Reiche

Steven M Blair

Hans-Hermann Oppermann

Rajmohan Bhandari

Michael Töpper

Prashant Tathireddy

Matthias Klein

Reid R Harrison

Prattay Deepta Kairy

Lars B Laurentius

Douglas A Christensen

Mahender Avula

Nassir F Marrouche

Carlos H Mastrangelo

Lothar Dietrich

Stan Kanarowski

Konstantin Shkurko

Klaus Buschick

Timothy John Garrett

Michael David Sorenson

Rami Sami Marrouche

Julia Koerner

Rajmohan Bandari

Loren Rieth

Michael Orthner

Sohee Kim

Jules John Magda

Mahender Nath Avula

Christopfer F Reiche

Systems and methods for measuring changes in smart hydrogel microresonator structures positioned in an in vivo or other environment, having an acoustic resonance frequency in an ultrasound range. The system includes a smart hydrogel microresonator structure positioned within the environment configured to exhibit a change in resonance frequency in response to interaction with one or more predefined analytes in the environment. The system includes an ultrasound transducer for querying the smart hydrogel microresonator structure at or near its resonance frequency. The system also includes a computer system configured to receive ultrasound data as provided by query of the smart hydrogel microresonator structure and to determine changes in resonance frequency, amplitude or intensity of the ultrasound query wave, or mean grayscale value (MGV) associated with the ultrasound data of the smart hydrogel microresonator structure due to the change in resonance frequency. Such change can be correlated to concentration of the analyte.

Implantable and biodegradable smart hydrogel micromechanical resonators with ultrasound readout for biomedical sensing

A weather-detecting device () can include a substrate () and a detection region () exposed to an environment within which the weather-detecting device () is situated when in use. An array () of heating elements () can be mounted at a first side of the substrate (), with at least one surface of each heating element () in the array () being positioned within the detection region (). A controller can be electrically coupled to the array () of heating elements (), and the controller can individually address each heating element () in the array () to selectively pass electrical current through each heating element ().

Weather-detecting devices and related methods

Systems and methods for accurately measuring changes in biomarker sensitive hydrogel volume and shape due to exposure to various biomarkers include a system for identifying one or more dimensional changes in a biomarker sensitive hydrogel positioned within an in vivo environment. The system includes a biomarker sensitive hydrogel positioned within an in vivo environment and configured to dimensionally change in response to interaction with predefined biomarkers. The system additionally includes an ultrasound transducer for locating and identifying one or more characteristics of the biomarker sensitive hydrogel and a computer system in electrical communication with the ultrasound transducer. The computer system is configured to receive characteristics of the biomarker sensitive hydrogel from the ultrasound transducer and determine dimensional changes of the biomarker sensitive hydrogel based on the received characteristics.

Ultrasound imaging of biomarker sensitive hydrogels

A sensor sheath for a catheter. The sensor sheath includes a substrate having at least one sensor associated therewith; and an electronics unit in communication with at the at least one sensor, wherein the substrate is configured to attach to a catheter.

Sensor systems

A method of fabricating an array of micro electrodes enabled to have customizable lengths. A substantially criss-cross pattern of channels on a top surface of the work-piece substrate () is formed using electrical discharge machining to form a plurality of shaped columns () having tapered profiles. The shaped columns have a tapering profile which extends at least 50% of the length of the columns. The plurality of shaped columns is etched to sharpen the tapered tips into needle tips forming the array of microelectrodes.

High aspect ratio microelectrode arrays enabled to have customizable lengths and methods of making the same

A micro-needle array having tips disposed along a non-planar surface is formed by shaping the wafer surface into a non-planar surface to define the tips of the micro-needles. A plurality of trenches are cut into the wafer to form a plurality of columns having tops corresponding to the non-planar surface. The columns are rounded and sharpened by etching to form the micro-needles.

Micro-needle arrays having non-planar tips and methods of manufacture thereof

An in-vivo implantable coil assembly includes a planar coil having at least one coil layer formed from conductive traces disposed in or on a polymer matrix. A ferrite platelet is bonded to a surface of the polymer matrix. Methods of making and using the in-vivo implantable coil assembly are also disclosed.

In vivo implantable coil assembly

A testing and analysis system for a pressure-sensitive device () that includes a testing stage () comprising a platform having a groove situated on an upper surface, an endless support gasket located in the endless groove, a pressure port located on the upper surface and interior to the endless groove, and a means for securing a substrate above the upper surface. The substrate () supports a pressure-sensitive device () to form a pressure chamber between the substrate () and the upper surface. A pressure source () is operatively connected to the pressure port to modify a pressure inside the pressure chamber and deflect the pressure-sensitive device (). A surface profile measurement apparatus () is included for measuring a surface profile of the deflected pressure-sensitive device ().

Apparatus, system and methods for analyzing pressure-sensitive devices

Methods for wafer-scale fabrication of needle arrays can include mechanically modifying a wafer to produce a plurality of vertically-extending columns. The columns are etched to round and reshape the columns into substantially uniformly shaped needles. Needle arrays having needle width non-uniformity of less than about 3% and length non-uniformity of less than about 2% can be produced.

Water-scale needle array

A method of fabricating a sub-millimeter scale curved surface on a substrate () includes cutting a plurality of trenches () of varying depth into the substrate (). The depth of the trenches () corresponds to a desired surface profile. The substrate () is etched to remove material left () between the trenches to form the curved surface.

Micro-lens arrays and curved surface fabrication techniques

Interconnect metallization schemes and devices for flip chip bonding are disclosed and described. Metallization schemes include an adhesion layer, a diffusion barrier layer, a wetable layer, and a wetting stop layer. Various thicknesses and materials for use in the different layers are disclosed and are particularly useful for metallization in implantable electronic devices such as neural electrode arrays.

Flip chip metallization method and devices

Growing community of inventors

Salt Lake City, UT, United States of America

Florian Solzbacher