Merck Patent Gmbh

F-star Biotechnologische Forschungs- Und Entwicklungsges.m.b.h

Florian Rüker

Gordana Wozniak-Knopp

Stefan Becker

Gerhard Stadlmayr

Sylvia Dietrich

Alec Gross

Jakub Rybka

Stephan Dickgiesser

Nicolas Rasche

Alec W Gross

A specific antigen-binding member (ABM) comprising a specific antigen-binding moiety and an antibody Fc region comprising a CH2 domain, which is engineered for a cysteine substitution at position 108 and/or 113, wherein numbering is according to the IMGT, and wherein the antibody Fc region does not comprise an antigen-binding CH3 domain; and an ABM conjugate (ABMC) comprising the ABM and at least one heterologous molecule covalently conjugated to one or both of the cysteines at positions 108 and 113 of the CH2 domain.

Cysteine engineered antigen-binding molecules

The invention provides for a domain-exchanged antibody comprising a light chain (LC) composed of VL-CH3, and a heavy chain (HC) comprising VH-CH3-CH2-CH3, wherein the VL-CH3 of the LC is dimerising with the VH-CH3 of the HC thereby forming a domain-exchanged LC/HC dimer comprising a CH3LC/CH3HC domain pair, and means and method for producing the same.

Domain-exchanged antibody

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Vienna, Austria

Florian Rüker