Roche Sequencing Solutions, Inc.

Ventana Medical Systems, Inc.

Florian Rubelt

Sedide Ozturk

Jan Berka

Seoyoung Kim

Brian Christopher Godwin

Joseph Platzer

Khai Luong

Carolina Dallett

Richard Dannebaum

Martin Ranik

Jainee Lewis

Jigar Patel

Stacey Stanislaw

Nelson Alexander

Aoune Barhoumi

Rui Chen

Toumy Guettouche

Lisa L Gallegos

Maeve E O'Huallachain

Dilduz Telman

The invention is a method of single cell transcriptome analysis. The method comprises detecting multiple transcripts in each individual cell of the plurality of cells by barcoding the transcripts with a cell-specific compound barcode formed using a DNA polymerase and a terminal transferase, optionally in a single enzyme such as a reverse transcriptase.

Whole transcriptome analysis in single cells

Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.

Immune profiling by primer extension target enrichment

The invention is a method of identifying a cognate antigen for a T-cell receptor using neoantigens from a patient's tumor cells combined with the patient's T-cells and using cell sorting, genome sequencing, expressing TCR genes, presenting tumor neoantigens on MHC complex and uniquely barcoding the T-cells where TCR recognition occurs to tag all components of the TCR recognition complex.

System for identification of antigens recognized by T cell receptors expressed on tumor infiltrating lymphocytes

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Menlo Park, CA, United States of America

Florian Rubelt