Mivenion Gmbh

Dendropharm Gmbh

Epiios Therapeutics Gmbh

Florian Paulus

Rainer Haag

Kai Licha

Michael Schirner

Marie Weinhart

Sam Moré

Christoph Stein

Emanuel Fleige

Pia Welker

Michael Unbehauen

Halina Machelska-Stein

Halina Machelska

The invention relates to the field of analgesics. According to the invention, a kit or composition, particularly a pharmaceutical composition or a pharmaceutical kit, is provided, comprising a nanocarrier which is a hyperbranched polymer, such as a dendritic polymer or dendrimer, preferably having a molecular weight of 1,000-100,000 g/mol, and an analgesic which, when administered without nanocarrier, has both peripheral and central analgesic effect, preferably an opioid such as nalbuphine. According to the invention, the analgesic in this composition mainly or exclusively has a peripheral effect and thus reduces side effects triggered by the activation of central or intestinal opioid receptors. It is used for the treatment of peripheral pain and/or inflammation. The invention also relates to particularly suitable nanocarriers.

Analgesic preparation with nanocarriers and use thereof

The present invention relates generally to methods and compositions for targeting of intracellular molecules involved in proliferation and protein synthesis of activated cells using polyanionic multivalent macromolecules. In particular aspect, multiple sulfate groups linked to polyol are specifically targeted to the cytoplasm and nucleus of proliferating and activated cells. The invention further comprises novel polyanionic macromolecular compounds and formulations.

Polyanionic multivalent macromolecules for intracellular targeting of proliferation and protein synthesis

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Munich, Germany

Florian Paulus