Centre National De La Recherche Scientifique

Université Montpellier 2 Sciences Et Techniques

Ecole Nationale Superieure De Chimie De Montpellier

Florian Monnier

Marc Taillefer

Ning Xia

Anis Tlili

Grégory Danoun

Anis Tlilli

The present invention concerns a process for creating a Carbon-Carbon bond (C&#x2014;C) or a Carbon-Heteroatom bond (C&#x2014;HE) by reacting a compound carrying a leaving group with a nucleophilic compound carrying a carbon atom or a heteroatom (HE) that can substitute for the leaving group, creating a C&#x2014;C or C&#x2014;HE bond, wherein the reaction takes place in the presence of an effective quantity of a. a catalytic system comprising a ligand and at least a metal-based catalyst, such a metal catalyst being chosen among iron or copper compounds proviso that only a single metal is present.

Catalytic system for cross-coupling reactions

The present invention concerns a process for preparing a compound of formula (I) by reaction between a compound of formula (II) and a compound of formula (III) in the presence of a copper-containing catalyst, a ligand and base. The invention also concerns the implementing of this process for the preparation of building blocks to prepare molecules of interest in particular in the pharmaceutical, agro-chemical fields, etc. 

Process for creating carbon-carbon bonds using carbonyl compounds

The present invention concerns a process for creating a Carbon-Carbon bond (C&#x2014;C) or a Carbon-Heteroatom bond (C-HE) by reacting a compound carrying a leaving group with a nucleophilic compound carrying a carbon atom or a heteroatom (HE) that can substitute for the leaving group, creating a C&#x2014;C or C-HE bond, wherein the reaction takes place in the presence of an effective quantity of a. a catalytic system comprising a ligand and at least a metal-based catalyst, such a metal catalyst being chosen among iron or copper compounds proviso that only a single metal is present.

The present invention relates to a method for the hydroxylation of halogen aryl compounds carried out at a temperature lower than 200&#xb0; C. in the presence of a catalytic system including a copper-based catalyst and a ligand L according to reaction scheme Formula (A), in which: R is selected from the groups having an acceptor inductive effect and the groups having a donor mesomer effect; M is selected from alkaline or alkaline-earth cations; X is a halogen atom; r is between 0 and 5; and the ligand L is selected from compounds having formula I. 

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Montpellier, France

Florian Monnier