Centre National De La Recherche Scientifique

Universite Claude Bernard – Lyon1

Hospices Civils De Lyon

Université Clermont Auvergne

Université René Descartes Paris 5

Centre National De La Recherche (cnrs)

Ecole Nationale Superieure De Chimie De Clermont Ferrand

Cnrs and Fabrice Duprat

Les Hospices Civils De Lyon

Florian Lesage

Michel Lazdunski

Michel Fink

Fabrice Duprat

Georges Romey

Eric Honore

Jacques Barhanin

Eric Guillemare

Veronique Annie Rogemond

Alain Eschalier

Jérôme Busserolles

Nuno Rodrigues

Sylvie Ducki

Francois Maingret

Amanda J Patel

Marie-Madeleine Larroque

Michel Mazzuca

Franck Chatelain

Delphine Vivier

Khalil Bennis

Jérome Honnorat

The present invention relates to the use of compounds for the treatment or prevention of pain in mammals, in particularly in human beings, and also to a process for preparing these compounds.

Pain relief compounds

The present invention relates to the field of medicine, in particular of research and diagnosis. It relates more particularly to a novel tool for detecting antibodies in a biological sample originating from a mammal. This tool, which is in the form of a protein chip, can be used in screening for new targets of interest involved in the occurrence of an autoimmune disease, in particular of a disease affecting the nervous system of a mammal, and also in the diagnosis or the monitoring of the progression of such an autoimmune disease. The invention also relates to a method for producing such a tool and also to kits comprising it and enabling its use.

Protein chips, preparation and use thereof

A purified protein including a mechanosensitive potassium channel activated by at least one polyunsaturated fatty acid and riluzole and the use of channels in drug screening.

Mechanosensitive mammalian potassium channel activatable by polyunsaturated fatty acids

Human and mouse TREK-1 potassium transport proteins are disclosed as well a method for using potassium transport proteins for identifying substances having anesthetic properties, such as producing a safe, reversible state of unconsciousness with concurrent amnesia and analgesia in a mammal upon inhalation, in a method comprising (a) contacting the test substance with a mammalian potassium transport protein, wherein said potassium transport protein exhibits outward-going potassium rectification; and (b) determining the potassium transport activity of the potassium transport protein, wherein an activation of potassium transport is indicative of the test substance having anesthetic properties.

Method for the identification of anesthetics

This invention relates to the cloning of a member of a new potassium channel named TWIK-1. More specifically, it relates to an isolated and purified nucleic acid molecule coding for a protein constituting a potassium channel exhibiting the proper-ties and structure of the TWIK-1 type channel, as well as the protein coded by this nucleic acid molecule. The invention also relates to the use of this nucleic acid molecule to transform cells, and the use of these cells expressing the potassium channels exhibiting the properties and structure of the TWIK-1 type channel for the screening of drugs.

Isolated TWIK-1 potassium channel proteins

This invention relates to a protein including a mammalian K+ channel with two pore domains, designated TREK2, that produces currents whose current-voltage relationship is weakly inward rectifying in high symmetrical K+ conditions. This invention further relates to the isolation and characterization of such protein, as well as a method using TREK2 to identify bioactive compounds having anesthetic properties.

Human TREK2, a stretch- and arachidonic acid-sensitive K+ channel activated by inhalational anesthetics and niluzole

A purified protein comprising a mechanosensitive potassium channel activated by at least one polyunsaturated fatty acid and riluzole and the use of such channels in drug screening.

Method for screening substances capable of modulating the activity of a TRAAK potassium channel

This invention relates to a new member of a recently recognized TWIK potassium,channel family, herein identified as TASK, for TWIK-related acid-sensitive K,channel. This is the first cloned mammalian channel that produces K,currents that possesses all the characteristics of background conductances. The invention also relates to various constructs including the TASK or related human potassium channel family, and their uses.

Family of mammalian potassium channels, their cloning and their use, especially for the screening of drugs

The present invention relates to the cloning of a member of a new potassium channel named TWIK-1. More specifically, it relates to an isolated and purified nucleic acid molecule coding for a protein constituting a potassium channel exhibiting the properties and structure of the TWIK-1 type channel, as well as the protein coded by this nucleic acid molecule. The invention also relates to the use of this nucleic acid molecule to transform cells, and the use of these cells expressing the potassium channels exhibiting the properties and structure of the TWIK-1 type channel for the screening of drugs.

Family of mammalian potassium channels, their cloning and their use

Growing community of inventors

Nice, France

Florian Lesage