Novartis Ag

Florian Karl Kleinbeck

Bernhard Erb

Isabelle Sylvie Gallou

Liladhar Murlidhar Waykole

Bernhard Wietfeld

Paul Allen Sutton

David Hook

Ulrich Meier

Bin Hu

Jean-Paul Mutz

Jan Schlomach

Sibylle Mueller

The invention relates to polymorphic forms of the calcium salt of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester. The calcium salt of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester is useful in the treatment of various conditions and disorders responsive to the inhibition of neutral endopeptidases.

Sacubitril calcium salts

Provided herein are processes and intermediate compounds useful for the preparation of 2-carboxamide cycloamino urea derivatives, and useful intermediates therefore.

Synthesis of 2-carboxamide cycloamino urea derivatives

Provided herein are processes useful for the preparation of 2-carboxamide cycloamino urea derivatives of formula (X), and useful intermediates therefore, at internal temperatures such as less than about &#x2212;5&#xb0; C. to about &#x2212;15&#xb0; C. and using solvents such as tetrahydrofuran, bases such as amines, and the like.

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Zurich, Switzerland

Florian Karl Kleinbeck