Medical Research Council

United Kingdom Research and Innovation

University of Cambridge

Imperial Innovations Limited

Hollfelder, Florian

Kaminski, Clemens

Crowther, Damian C.

Van Vliet, Liisa

Gielen, Fabrice

Kaminski, Gabi

Fischlechner, Martin

Bauer (Nee Yan), Jing

Florian Hollfelder

Andrew David Griffiths

Chris Abell

Enrico Mastrobattista

The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, by compartmentalizing the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsules; and identifying the compound which binds to or modulates the activity of the target. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.

Selection by compartmentalized screening

Methods for use in the synthesis and identification of molecules which bind to a target component of a biological system or modulate the activity of a target are described.

Method of synthesis and testing of combinatorial libraries using microcapsules

Selection by compartmentalised screening

The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a.) compartmentalizing the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsules; and b.) identifying the compound which binds to or modulates the activity of the target. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.

The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalizing two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets. The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalized into the microcapsules.

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Cambridge, United Kingdom

Florian Hollfelder