Commonwealth Scientific and Industrial Research Organisation

Polyactiva Pty Ltd

Florian Hans Maximilian Graichen

Michael Shane O'Shea

Russell John Tait

Benjamin Aldo Leita

Andrew Craig Donohue

Sarah Man Yee Ng

Adrian Sulistio

Asha Marina D'Souza

Justine Leigh Jeffery

Heng Chy Taing

The invention relates to polymer-drug conjugate for delivering a substituted alkanoic acid non-steroidal anti-inflammatory drug (NSAID). The invention also relates to drug delivery systems comprising the polymer-NSAID conjugate. The polymer-NSAID conjugates comprise a substituted alkanoic acid non-steroidal anti-inflammatory drug (NSAID) conjugated to a biodegradable polymer backbone by an ester linkage.

Polymer-NSAID conjugate

Monomers having the structure and a polymer comprising as part of its polymer backbone a moiety of Formula (II): where one of Rto Rrepresents A-O&#x2014; and one of Rto Rrepresents &#x2014;O&#x2014;B and the remainder of Rto Rrepresent H, where A and B represent the remainder of the polymer backbone and may be the same or different. The monomers are diol, dicarboxylic acid, epoxy, and succinate compounds containing a cineole structure wherein a compound for use in preparation of polymer, the compound selected from 

Polymeric materials

A polymer comprising as part of its polymer backbone a cineole-type moiety having a structure according to Formula (II): 

The invention relates to a biodegradable polymer comprising a plurality of releasable bioactive moieties, the releasable bioactive moieties being pendant from and covalently bonded to the biodegradable polymer backbone, wherein the biodegradable polymer backbone is formed from monomeric units that are each coupled via a biodegradable moiety, and wherein the bioactive moieties are capable of being released at a rate equal to or faster than the rate of biodegradation of the polymer backbone.

Growing community of inventors

Richmond, Australia

Florian Hans Maximilian Graichen