Tron—translationale Onkologie An Der Universitatsmedizin Der Johannes Gutenberg-Universitat Mainz Ggmbh

Biontech Se

Biontech Rna Pharmaceuticals Gmbh

Tron—translationale Onkologie An Der Universitátsmedizin Der Johannes Gutenberg—universitÄt Mainz Gemeinnützige Gmbh

Florian Eberle

Ugur Sahin

Mustafa Diken

Andreas Kuhn

Britta Vallazza

The present invention relates to nucleic acid molecules containing poly (dA:dT) regions which are stabilized in.-, methods of propagating such nucleic acid molecules in, methods of obtaining RNA, peptides or proteins using such nucleic acid molecules and to RNA which is obtained from such nucleic acid molecules and its use. In particular, the poly (dA:dT) regions contain at least one disruption by a sequence not encoding a sequence solely composed of A residues.

Stabilization of poly(A) sequence encoding DNA sequences

The present invention relates to nucleic acid molecules containing poly (dA:dT) regions which are stabilized in, methods of propagating such nucleic acid molecules in, methods of obtaining RNA, peptides or proteins using such nucleic acid molecules and to RNA which is obtained from such nucleic acid molecules and its use. In particular, the poly (dA:dT) regions contain at least one disruption by a sequence not encoding a sequence solely composed of A residues.

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Dossenheim, Germany

Florian Eberle