Children's Medical Center Corporation

Pfizer Corporation

Florian E Winau

Chew Shun Chang

Nicholas Andrew Marze

Di Wu

Ji Hyung Kim

Shian-Huey Chiang

Oleg V Kovalenko

Antibodies, and antigen-binding fragments thereof, that specifically bind to Cluster of Differentiation 1a (CD1a) are provided. Embodiments include uses, and associated methods of using the antibodies, and antigen-binding fragments thereof.

CD1a antibodies and uses thereof

The methods, compositions, and assays described herein are based, in part, on the discovery that CD1a mediates inflammation related to certain conditions such as urushiol exposure, psoriasis and other inflammatory skin diseases. One aspect provided herein relates to a method for treating or preventing an inflammatory skin disease, the method comprising: administering a therapeutically effective amount of an inhibitor of CD 1a to a subject having an inflammatory skin disease, thereby treating or preventing the inflammatory skin diseases.

Treatment of inflammatory skin disease

Growing community of inventors

Boston, MA, United States of America

Florian E Winau