Leica Biosystems Nussloch Gmbh

Evonik Operations Gmbh

Florian Böhl

Hermann Ulbrich

Markus Berberich

Ralf Eckert

Karin Flieger

Richard Ducatelle

Filip Van Immerseel

Stella Louise Knorr

Alexander Reth

Stefan Pelzer

Andrew Guy

Evy Goossens

Monika Flügel

Frank Thiemann

Sarah Hark

David L Wicker

Andreas Kappel

Frank Lyko

Emeka Ignatius Igwe

Michelle Dargatz

Michaela Weissmann

Casey Middlebrooks

Sarah Tilley

Janet Smith

Ken Martin

Günter Raddatz

The present invention relates to a method for detectinginduced diseases in animals, the method comprising: a) collecting sample material of a specific animal or of a specific group of animals at consecutive points in time; b) determining the amount of a first marker and a second marker contained in the sample material; and c) determining the ratio of the first marker to the second marker contained in the sample material; wherein the first marker comprises a polynucleotide sequence being specific for thesub-species inducing the targeted disease; and the second marker comprises a polynucleotide being specific for the species; and wherein an increase in the ratio of the first marker to the second marker in the analyzed sample material over time is an indication of the targeted disease.

Method for detectinginduced diseases in animals

The invention relates to a method for embedding a tissue sample into an embedding medium. In a first step the tissue sample is held in an intended orientation in a container by means of a holding element that presses the tissue sample against a base of the container. In a further step a liquid embedding medium that has a temperature above 64 degrees Celsius, in particular in the range from 65 degrees Celsius to 67 degrees Celsius, or a temperature of 66 degrees Celsius, is poured into the container, and the base of the container is cooled. In a further step a separating motion is executed by way of which the tissue sample and the holding element move away from each other, those layers of the embedding medium through which the holding element moves during the separating motion having, during the separating motion, temperatures in the range from 54 degrees Celsius to 64 degrees Celsius, in particular of 60 degrees Celsius, and/or those portions of the embedding medium which are directly adjacent to the holding element having, during the separating motion, a temperature in the range from 54 degrees Celsius to 64 degrees Celsius, in particular of 60 degrees Celsius.

Method and automatic machine for embedding a tissue sample into an embedding medium

The invention relates to a melting apparatus () for melting paraffin (), having: a melting container () for receiving paraffin () to be melted; a storage container () for storing molten paraffin (); having a melting container heating device () for heating the melting container (), having a storage container heating device () for heating the storage container (), having a fluid connection () fluidically connecting the melting container () and the storage container; the melting container (), the storage container (), and the fluid connection () being arranged so that molten paraffin () flows out of the melting container () into the storage container ().

Melting apparatus for metered melting of paraffin

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Neckargemünd, Germany

Florian Böhl