Ciba-geigy Corporation

Gesellschaft Fur Biotechnologische Forschung Mbh

Helmholtz-zentrum Fur Infektionsforschung Gmbh

Medizinische Hochschule Hannover

Helmholtz-zentrum Fuer Infektionsforschung Gmbh

Gesellschaft Fuer Biotechnologische Forschung Mbh (gbf)

Hemholtz-zentrum Fur Infektionsforschung Gmbh

Florenz Sasse

Heinrich Steinmetz

Klaus Gerth

Hans Reichenbach

Rolf Jansen

Herbert Irschik

Gerhard Hoefle

Norbert Bedorf

Brigitte Kunze

Johannes P Pachlatko

Wolfram Trowitzsch-Kienast

Edgar Forche

Gerhard H Ofle

Ingo Hardt

Gerhard Hofle

Thomas Leibold

Nicole Glaser

Nisar Malek

Bettina Hinkelmann

Roland Frank

Irina Nickeleit

Ronald Frank

The present invention relates to the use of particular macrocycles that are inhibitors of the proteasomic degradation of p27, in particular Argyrin and derivatives thereof, preferably Argyrin A, for the treatment of proliferative diseases, such as cancer, as well as the derivatization of said macrocycles.

Use of inhibitors of the degradation of p27, in particular Argyrin and derivatives thereof, for the treatment of proliferative diseases

The present invention relates to a novel group of compounds having antibiotic, antifungal and/or cytostatic properties, which are obtainable from myxobacteria, especially of the genus, preferably. One representative of this group of compounds is currently named Disorazole Z and Disorazole Z-epoxide, respectively, with specific substituents and specific unsaturated bonds to its cyclic core structure: 

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The invention relates to a compound of the following general formula (tubulysin) having the following meanings for R, R, R, R, R, R, R, R, R, R, R, R, S, T, U, V, W, X, Y and Z: 

Tubulysins, method for producing the same and tubulysin preparations

The invention concerns compounds which can be obtained by fermenting DSM 6773, especially epothilones A1, A2, A8, A9, B10, C1, C2, C3, C4, C5, C6, C7, C8, C9, D1, D2, D5, G1, G2, H1, H2, I1, I2, I3, I4, I5, I6 and K and trans-epothilones C1 and C2.

Epothilone side components

The invention relates to compounds which are obtained by fermenting DSM 6773, especially epothilones A1, A2, A8, A9, B10, C1, C2, C3, C4, C5, C6, C7, C8, C9, D1, D2, D5, G1, G2, H1, H2, I1, I2, I3, I4, I5, I6 and K and trans-epothilones C1 and C2.

Epothilone minor constituents

The invention relates to compounds of the following general formula I ##STR1## especially the compound of formula Ia referred to as thiangazole ##STR2## their pharmaceutically acceptable acid addition salts, processes for their preparation and therapeutic compositions and compositions that can be used in crop-protection.

Thiangazole, its preparation, compositions and use thereof

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Braunschweig, Germany

Florenz Sasse