Institut National De La Sante Et De La Recherche Medicale

University of Utah Research Foundation

Univ. of Utah Research Foundation

Florent Soubrier

Pierre Corvol

Jean-Marc Lalouel

Richard P Lifton

Xavier Jeunemaitre

Youri Kotelevtsev

Christine Hubert

Francois Alhenc-Gelas

Francedillaois Alhenc-Gelas

The association of the molecular variant G-6A of the angiotensinogen gene with human hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to high blood presure.

Method to determine predisposition to hypertension

The association of the molecular variant G-6A of the angiotensinogen gene with human hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to high blood pressure.

The object of the invention is the cloning and sequencing of the nucleic acid coding for the human testicular ACE as well as the determination of the peptide sequence of this ACE. It relates more particularly to the use of nucleotide probes capable of hybridizing with all or part of the above-mentioned nucleic acid, and also the polyclonal or monoclonal antibodies recognizing specifically all or part of the above-mentioned peptide sequence, and the use of these probes or these antibodies for the implementation, respectively, of a method for the detection of the messenger RNA coding for the testicular ACE in vitro or of the testicular ACE directly.

Nucleic acid coding for the human testicular angiotensin converting

Agents and procedures for the study of the genetic polymorphism of the

The association of molecular variants of the angiotensinogen gene with human essential hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to high blood presure.

Angiotensinogen gene variants and predisposition to hypertension

The invention relates to the cloning and sequencing of the nucleic acid coding for the human ACE as well as the determination of the peptide chain corresponding to the ACE and of active peptide fragments which derive from it. Another subject of the invention is the utilization of the above-mentioned polypeptides for the implementation of in vitro diagnostic methods for hypertension and for the design of new inhibitors of the ACE. The invention also relates to the utilization of the nucleotide probes of the invention for the in vitro screening of the polymorphisms of the gene coding for the ACE.

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Paris, France

Florent Soubrier