Cardiomems, Inc.

St. Jude Medical Luxembourg Holdings Ii S.a.r.l. (“Sjm Lux 11”)

Georgia Tech Research Corporation

Tc1 LLC

St. Jude Medical Luxembourg Holdings Ii S.a.r.l.

St. Jude Medical Luxembourg Holdings Ii S.a.r.l. (“Sjm Lux Ii”)

St. Jude Medical Luxenbourg Holdings Ii S. A. R. L (“Sjm Lux Ii”)

Florent Cros

Jin Woo Park

Michael Fonseca

David O'Brien

Angad Singh

Matthew Abercrombie

Mark G Allen

Christophe Courcimault

Jason Kroh

Liang You

Jin-Woo Park

Kevin Corcoran

Miguel Luis Berr

Jay Yadav

Emmanouil Tentzeris

Yong-Kyu Yoon

Ioannis Papapolymerou

Yeun-Ho Joung

Bo Pan

Kim Kieun

David O'brien

Jay S Yadev

Mark Allen

A system and method are provided for determining a pressure associated with a lumen of a body. A wireless sensor is positioned in the lumen of the body. The sensor comprises an LC resonant circuit having a resonant frequency configured to vary in response to changes in pressure in the lumen. One or more sensor calibration parameters are stored at an external base unit. The external based unit generates and transmits an energizing signal. A ring down response is received from the wireless sensor. The system and method determine the resonant frequency of the LC resonant circuit from the ring down response and calculate the pressure in the lumen from the resonant frequency of the LC resonant circuit utilizing the one or more sensor calibration parameters associated with the LC resonant circuit.

System and method for calculating a lumen pressure utilizing sensor calibration parameters

An implantable wireless sensor is provided for determining a pressure of a lumen in a body. The sensor comprises a sensor body comprising a plurality of substrates, at least a portion of the substrates comprising a first dielectric material. An LC resonant circuit is contained with the sensor body. A capacitance of the LC resonant circuit is configured to vary in response to changes in pressure in the lumen. A first anchoring element is coupled to a proximal end of the sensor body and a second anchoring element is coupled to a distal end of the sensor body. The first and second anchoring elements are configured to lodge the sensor body within the lumen. A second dielectric material, different than the first dielectric material, is provided over at least a portion of at least one of the plurality of substrates.

Implantable wireless pressure sensor

A system and method are provided to deploy an implant assembly in a vessel. The implant assembly comprises a pressure sensor having a body, and first and second anchoring members coupled to the body of the pressure sensor. A delivery apparatus comprises a shaft having proximal and distal ends, the shaft including a main lumen and a secondary lumen, the main lumen extending along at least a portion of the shaft. The secondary lumen extends along at least a portion of the length of the shaft, the secondary lumen joined with first and second ports provided in a sidewall of the shaft. A tether wire is configured to be slidably positioned within the secondary lumen, the tether wire having a distal portion configured to secure the implant assembly against the sidewall.

System for deploying an implant assembly in a vessel

A method and system are provided for determining a pressure associated with a lumen of a patient. A wireless sensor is positioned in the lumen of the patient. The sensor has a body with a pressure sensitive surface, including a sealed cavity that holds an inductive-capacitive (LC) resonant circuit. A capacitance of the LC resonant circuit is configured to vary in response to changes in pressure in the lumen. The LC resonant circuit has a charge time related to a quality factor (Q) of the LC resonant circuit. The LC resonant circuit is energized with an energizing signal during a measurement cycle. The energizing signal has a duty cycle with an on-time that is set, in part, based on the charge time. A ring down response is received from the wireless sensor. The ring down response is utilized to calculate the pressure associated with the lumen of the patient.

Method and system for determining a lumen pressure

An implantable wireless sensor is provided that comprises a plurality of substrates joined together to form a body with a hermetically sealed cavity therein. A capacitor (C) is provided within the cavity. A first capacitor plate is formed on an internal surface of the first substrate. An inductor (L) is provided within the cavity and coupled to form an LC resonant circuit. At least a portion of the first substrate comprises a deflectable region mechanically coupled to the first capacitor plate. The deflectable region is configured to deflect in response to changes in pressure in the artery altering a spacing between the capacitor plates and altering a resonant frequency of the LC resonant circuit. First and second anchoring elements are coupled to the body and include flexible wire loops configured to extend outward from the body to lodge within a lumen of the artery.

Wireless sensor for measuring pressure

A pressure sensor is provided that comprises an upper wafer formed from a dielectric material, the upper wafer having channels. The upper wafer includes a first capacitor plate and a second capacitor plate formed on a lower surface of the upper wafer. An inductor is contained within the channels in the upper wafer in fixed relation to the first and second capacitor plates. A lower wafer is formed from the dielectric material. A third capacitor plate is formed on an inner surface of the lower wafer. The upper and lower wafers are fused together to form a monolithic housing such that the first and second capacitor plates are arranged in parallel, spaced-apart relation from the third capacitor plate. The lower wafer comprising a pressure sensitive deflective region underlying the third capacitor plate. The deflective region deflects in response to changes in ambient pressure in the medium.

A method of manufacturing a sensor for in vivo applications includes the steps of providing two wafers of an electrically insulating material. A recess is formed in the first wafer, and a capacitor plate is formed in the recess of the first wafer. A second capacitor plate is formed in a corresponding region of the second wafer, and the two wafers are affixed to one another such that the first and second capacitor plates are arranged in parallel, spaced-apart relation.

Method of manufacturing implantable wireless sensor for pressure measurement

Wireless sensors configured to sense, record and transmit data are provided herein. In one aspect, the wireless sensor has a power harvesting unit; a transducing A-to-D converter unit, a microcontroller unit, and a transmitting coil. The power harvesting unit is configured to receive an external energizing magnetic field generated by an external interrogator and store the energy generated thereby. The transducing A-to-D converter unit has a passive electrical transducer configured to respond to variations in a physical property and a converter configured to measure a characteristic value of the passive electrical transducer and provide a digital signal that is indicative of the measured characteristic value. The microcontroller unit is electrically coupled to the power harvesting unit and the transducing A-to-D converter unit and is configured to receive the digital signal from the transducing A-to-D converter unit. The transmitting coil is configured to receive the digital signal and to transmit the digital signal to the external interrogator. Upon receiving a start signal, the transducing A-to-D converter unit charges a current through the passive electrical transducer until a reference voltage is reached and, upon reaching the reference voltage, the microcontroller unit receives the digital signal.

Physical property sensor with active electronic circuit and wireless power and data transmission

Method of manufacturing implantable wireless sensor for in vivo pressure measurement

Wireless sensors configured to record and transmit data as well as sense and, optionally, actuate to monitor physical properties of an environment and, optionally, effect changes within that environment. In one aspect, the wireless sensor can have a power harvesting unit; a voltage regulation unit, a transducing oscillator unit, and a transmitting coil. The voltage regulation unit is electrically coupled to the power harvesting unit and is configured to actuate at a minimum voltage level. The transducing oscillator unit is electrically coupled to the voltage regulation unit and is configured to convert a sensed physical property into an electrical signal. Also, the transmitting coil is configured to receive the electrical signal and to transmit the electrical signal to an external antenna.

A method for providing an in-vivo assessment of relative movement of an implant that is positioned in a living being is provided wherein a first assembly and a second assembly are positioned within the living being. The first assembly includes a passive electrical resonant circuit that is configured to be selectively electromagnetically coupled to an ex-vivo source of RF energy and, in response to the electromagnetic coupling, generates an output signal characterized by a frequency that is dependent upon a distance between the first assembly and the second assembly at the time of the electromagnetic coupling.

System, apparatus, and method for in-vivo assessment of relative position of an implant

A ventricular shunt systems and methods of preventing hydrocephalus are described herein. In one aspect, the ventricular shunt system has at least one pressure sensor that is configured to be selectively electromagnetically coupled to an ex-vivo source of RF energy and is variable in response to the pressure in a patient's ventricle.

Ventricular shunt system and method

A wireless sensor having a primary passive electrical resonant circuit that has an intrinsic electrical property that is variable in response to a characteristic of a patient and a secondary passive electrical resonant circuit. In one aspect, the primary passive resonant circuit can be positioned into a tuned position in response to the actuation of the secondary passive electrical resonant circuit. In a further aspect, in the tuned position, the primary passive electrical resonant circuit, in response to an energizing signal produced by an ex-vivo source of RF energy, is configured to generate a sensor signal characterized by a resonant frequency that is indicative of the characteristic.

Selectively actuating wireless, passive implantable sensor

This application relates to an apparatus and system for sensing strain on a portion of an implant positioned in a living being. In one aspect, the apparatus has at least one sensor assembly that can be mountable thereon a portion of the implant and that has a passive electrical resonant circuit that can be configured to be selectively electromagnetically coupled to an ex-vivo source of RF energy. Each sensor assembly, in response to the electromagnetic coupling, can be configured to generate an output signal characterized by a frequency that is dependent upon urged movement of a portion of the passive electrical resonant circuit and is indicative of strain applied thereon a portion of the respective sensor assembly.

Growing community of inventors

Decatur, GA, United States of America

Florent Cros