Novo Nordisk A/s

Other

High Point Pharmaceuticals, LLC

Florencio Zaragoza Dorwald

Knud Erik Andersen

Rolf Hohlweg

Bernd Peschke

Klaus Rudolf

Dirk Stenkamp

John Bondo Hansen

Rudolf Hurnaus

John Patrick Mogensen

Jane Marie Lundbeck

Anker S Jorgensen

Inge Thoger Christensen

Ulla Grove Sidelmann

Tina Moller Tagmose

Bernd Krist

Stephan Georg Muller

Jesper F Lau

Thomas Kruse Hansen

Birgitte Langer Eriksen

Lauge Schaffer

Jan Lindy Sørensen

Birgitte Eriksen

Certain novel benzothiazoles and benzoxazoles, e.g., 2-(piperazin-1-yl)benzothiazoles and 2-(piperazin-1-yl)benzoxazoles, optionally substituted in the 3 and/or 4 positions of the piperazine rings, having histamine H3 antagonistic activity can be used in pharmaceutical compositions.

Benzothiazoles having histamine H3 receptor activity

The invention relates to protracted GLP-1 compounds and therapeutic uses thereof.

Extended GLP-1 compounds

Certain novel benzothiazoles and benzoxazoles, e.g., 2-(piperazin-1-yl)benzothiazoles and 2-(piperazin-1-yl)benzoxazoles, optionally substituted in the 3 and/or 4 positions of the piperazine rings,! of the general formula (1): having histamine H3 antagonistic activity can be used in pharmaceutical compositions.

Method for increasing half-life of therapeutic agents in plasma and novel polypeptide derivatives.

Plasma protein affinity tags

A novel class of substituted piperidines, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.

Substituted piperidines

A novel class of substituted piperazines and diazepanes, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.

Substituted piperazines and diazepanes

A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.

Imidazole compounds

Novel aminoazetidine, -pyrrolidine, and -piperidine derivatives, use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, and a method of treatment employing these compounds and compositions. The compounds show a high and selective binding affinity to the histamine H3 receptor indicating histamine H3 receptor antagonistic, inverse agonistic or agonistic activity. As a result, the compounds are useful for the treatment of diseases and disorders related to the histamine H3 receptor.

Aminoazetidine,-pyrrolidine and -piperidine derivatives

Imidazo heterocyclic compounds

Substituted imidazoles, their preparation and use

Substituted 3,3-diamino-2-propenenitriles, their preparation and use

A solid phase method for the synthesis of a plurality of differently substituted 2-methylenethiazoles with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The 2-methylenethiazoles are prepared by acylation of a substrate-bound primary or secondary amine with cyanoacetic acid and reaction of the resulting cyanoacetamide with an isothiocyanate in the presence of a base. Alkylation with an appropriate alkyl halide under acidic conditions yields differently substituted, support-bound 2-methylene-2,3-dihydrothiazoles. These may be screened on the substrate or cleaved from the substrate and then screened in solution. The efficient synthesis of a wide variety of 2-methylenethiazoles using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiazole-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

Solid phase and combinatorial synthesis of substituted 2-methylene-2,

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Ballerup, Denmark

Florencio Zaragoza Dorwald