Meristem Therapeutics S.a.

Meristem Therapeutics

Florence Ruggiero

Veronique Gruber

Bertrand Merot

Philippe Bournat

Stephanie Perret

Jean-Yves Exposito

Robert Garrone

Jeanne Comte

The present invention relates to a process for the production of fibres of an unhydroxylated recombinant collagen polypeptide, and the fibres obtained thereby, as well as to uses of such fibres as a biomaterial.

Method for the manufacture of recombinant unhydroxylated collagen polypeptide fibres, and recombinant unhydroxylated collagen polypeptide fibres obtained thereby

The invention concerns the use of a recombinant nucleotide sequence containing a cDNA coding for one or several mammalian collagen chains or derived proteins and elements enabling a plant cell to produce the collagen chains(s) or derived proteins, coded by said cDNA, particularly a transcription promoter and terminator identified by the transcription machinery of the plant cells, for transforming the plant cells so as to obtain from these cells, or plants obtained from them, the collagen chain(s) or derived proteins. The invention also concerns the resulting proteins and transformed plant material as well as their uses.

Recombinant collagen and derived proteins produced by plants, methods for obtaining them and uses

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Villeurbanne, France

Florence Ruggiero