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University of California

Université´ D'aix-Marseille

Le Centre National De Recherche Scientifique (cnrs)

L'institut National Des Sciences Appliquees (insa)

Centre National De La Recherche Scientifique

Florence Mingardon

Henri-Pierre Fierobe

Angélique Chanal-Vial

Angelique Chanal

Taek Soon Lee

Aindrila Mukhopadhyay

Brett Garabedian

Corey Meadows

The present invention provides for a genetically modified host cell capable of reducing one or more isoprenoid, or precursor thereof, said genetically modified host cell comprising one or more geranylgeranyl reductases (GGRs), or polypeptides comprising an amino acid sequence having at least 70% identity to an amino acid sequence of a geranylgeranyl reductase (GGR), wherein the polypeptide comprises the enzymatic activity for catalyzing one or more GGR catalyzed reactions, and/or reducing one or more Cor Cprenyl alcohols or prenyl pyrophosphates.

Host cells and methods for reducing isoprenoid precursors and isoprenoids by geranylgeranyl reductase

The present invention provides methods for improving microbial tolerance to alpha olefin compounds, host cells having increased tolerance to such compounds, and method of using the host cells to produce alpha olefin compounds.

Modified host cells having tolerance to &#x3b1;-olefins

Described herein are molecules, constructs and methods for the production and secretion of polypeptides of interest by host cells, preferably bacterial host cells, and more particularly gram positive bacteria. In particular, the present invention is related to a polynucleic acid encoding a fusion protein and to uses thereof for the secretion of heterologous or homologous polypeptides of interest by a bacterial host cell, preferablybacteria. The present invention further relates to methods and constructs for the production and secretion of heterologous or homologous polypeptides of interest proteins by host cells using such polynucleic acids and fusion proteins.

Constructs and methods for the production and secretion of polypeptides

Growing community of inventors

Pasadena, CA, United States of America

Florence Mingardon