Sanofi-aventis

Florence Medaisko

Gihad Dargazanli

Genevieve Estenne-Bouhtou

Christian Hoornaert

Ahmed Abouabdellah

Adrien Tak Li

Michele Bas

Nathalie Rakotoarisoa

Maria-Carmen Renones

Mireille Sevrin

Pierre M Roger

Corinne Veronique

Pascale Magat

Benoît Marabout

Geneviève Estenne-Bouhtou

A compound corresponding to general formula (I): in which Rrepresents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C-C)alkyl, (C-C)alkoxy, trifluoromethyl, trifluoromethoxy, benzyloxy, (C-C)cycloalkyl-O&#x2014; or (C-C)cycloalkyl(C-C)alkoxy groups; Rrepresents either a group of general formula CHRCONHRin which Rrepresents a hydrogen atom or a methyl group and Rrepresents a hydrogen atom or a (C-C)alkyl, (C-C) cycloalkyl or (pyridin-4-yl)methyl group; or a 2,2,2-trifluoroethyl group; or an (imidazol-2-yl)methyl group; or a (benzimidazol-2-yl)methyl group; or a phenyl group optionally substituted with one or more halogen atoms or cyano, nitro, (C-C)alkyl, (C-C)alkoxy, trifluoromethyl or trifluoromethoxy groups; and n represents a number ranging from 1 to 3; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. Also disclosed and claimed are the pharmaceutical compositions derived therefrom and their therapeutic use in treating a wide variety of diseases.

Derivatives of dioxan-2-alkyl carbamates, preparation thereof and application thereof in therapeutics

A compound corresponding to general formula (I): in which Rrepresents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C-C)alkyl, (C-C)alkoxy, trifluoromethyl, trifluoromethoxy, benzyloxy, (C-C)cycloalkyl-O&#x2014; or (C-C)cycloalkyl(C-C)alkoxy groups; Rrepresents either a group of general formula CHRCONHRin which Rrepresents a hydrogen atom or a methyl group and Rrepresents a hydrogen atom or a (C-C)alkyl, (C-C)cycloalkyl or (pyridin-4-yl)methyl group; or a 2,2,2-trifluoroethyl group; or an (imidazol-2-yl)methyl group; or a (benzimidazol-2-yl)methyl group; or a phenyl group optionally substituted with one or more halogen atoms or cyano, nitro, (C-C)alkyl, (C-C)alkoxy, trifluoromethyl or trifluoromethoxy groups; and n represents a number ranging from 1 to 3; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. Also disclosed and claimed are the pharmaceutical compositions derived therefrom and their therapeutic use in treating a wide variety of diseases.

The disclosure relates to a compound of formula (I): wherein m, n, Ar, and R are as defined in the disclosure, to compositions containing them and to their therapeutic use. The disclosure also relates to processes for preparing these compounds and to certain intermediate compounds.

Derivatives of pyrrolizine, indolizine and quinolizine, preparation thereof and therapeutic use thereof

Compounds of formula (I) as defined herein: are useful for treating behavioral disorders associated with dementia, psychoses, in particular schizophrenia (deficient form and productive form) and acute or chronic extrapyramidal symptoms induced by neuroleptics; for the treatment of various forms of anxiety, panic attacks, phobias, and compulsive obsessive disorders; for treating various forms of depression, including psychotic depression; for treating disorders caused by alcohol abuse or weaning from alcohol, sexual behavior disorders, eating disorders and for treating migraine. Moreover, the compounds of the invention may be used for treating painful muscle contracture in rheumatology and in acute spinal pathology; for treating spastic contractures of medullary or cerebral origin; for the symptomatic treatment of acute and subacute pain of light to moderate intensity; for treating intense and/or chronic pain, neurogenic pain and intractable pain; for treating Parkinson's disease and Parkinson-like symptoms of neurodegenerative origin or induced by neuroleptics; for treating partial primary and secondary generalized epilepsy of simple or complex symptomology, mixed forms and other epileptic syndromes in addition to another antiepileptic treatment, or in monotherapy, for the treatment of sleep apnea, and for neuroprotection.

Derivatives of N-[phenyl(pyrrolidine-2-YL)methyl]benzamide and N-[(azepan-2-YL) phenylmethyl]benzamide, preparation method thereof and application of same in therapeutics

Derivatives of N-[heteroaryl(piperidine-2-yl) methyl]benzamide, preparation method thereof and application of same in therapeutics

The present invention discloses and claims a compound of general formula (I) wherein A, X and Rare as described herein. Also disclosed and claimed is application of this compound in a variety of therapeutic applications.

N-[Phenyl(piperidin-2-yl)methyl]benzamide derivatives, their preparation and their application in therapy

Compounds of formula (I) as defined herein: are useful for treating behavioral disorders associated with dementia, psychoses, in particular schizophrenia (deficient form and productive form) and acute or chronic extrapyramidal symptoms induced by neuroleptics; for the treatment of various forms of anxiety, panic attacks, phobias, and compulsive obsessive disorders; for treating various forms of depression, including psychotic depression; for treating disorders caused by alcohol abuse or weaning from alcohol, sexual behavior disorders, eating disorders and for treating migraine.

Derivatives of N-[phenyl(pyrrolidine-2-yl)methyl]benzamide and N-[(azepan-2-yl)phenylmethyl]benzamide, preparation, and use in treatment of schizophrenia

A compound corresponding to general formula (I): in which Rrepresents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C&#x2013;C)alkyl, (C&#x2013;C)alkoxy, trifluoromethyl, trifluoromethoxy, benzyloxy, (C&#x2013;C)cycloalkyl-O&#x2014; or (C&#x2013;C)cycloalkyl(C&#x2013;C)alkoxy groups; Rrepresents either a group of general formula CHRCONHRin which Rrepresents a hydrogen atom or a methyl group and Rrepresents a hydrogen atom or a (C&#x2013;C)alkyl, (C&#x2013;C)cycloalkyl or (pyridin-4-yl)methyl group; or a 2,2,2-trifluoroethyl group; or an (imidazol-2-yl)methyl group; or a (benzimidazol-2-yl)methyl group; or a phenyl group optionally substituted with one or more halogen atoms or cyano, nitro, (C&#x2013;C)alkyl, (C&#x2013;C)alkoxy, trifluoromethyl or trifluoromethoxy groups; and n represents a number ranging from 1 to 3; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. Also disclosed and claimed are the pharmaceutical compositions derived therefrom and their therapeutic use in treating a wide variety of diseases.

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Saint Maur des Fosses, France

Florence Medaisko