Epimmune Inc.

Florence Dal Degan

Mark Joseph Newman

Scott Southwood

Jeffery L Alexander

Mark J Newman

The present invention provides novel artificial oligopeptides capable of binding HLA Class II molecules encoded by several alleles. The oligopeptides include the sequence AXFVAAXTLXAXA (SEQ ID NO:1), wherein Xis selected from the group consisting of W, F, Y, H, D, E, N, Q, I and K; Xis selected from the group consisting of F, N, Y and W; Xis selected from the group consisting of H and K, and Xis selected from the group consisting of A, D and E, with the proviso that the oligopeptide sequence is not AKFVAAWTLKAAA. The invention also relates to larger peptides comprising the oligopeptides, polynucleotides encoding the oligopeptides and larger peptides, as well as to compositions comprising the oligopeptides, peptides or polynucleotides. Also disclosed are methods for inducing immune responses.

Growing community of inventors

Virum, Denmark

Florence Dal Degan