H. Lundbeck A/s

Florence Dal Degan

Peter Birk Rasmussen

Klaus Gregorius Nielsen

Martin Roland Jensen

Peter Koefoed

Disclosed are novel methods and compositions for combating diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloid precursor protein (APP) or beta amyloid (A&#x3b2;). Immunization is preferably effected by administration of analogs of autologous APP or A&#x3b2;, said analogs being capable of inducing antibody production against the autologous amyloidogenic polypeptides. Especially preferred as an immunogen is autologous A&#x3b2; which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes. Such methods and means include methods for the preparation of analogs and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.

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Horsholm, Denmark

Florence Dal Degan