University of Pennsylvania

Fletcher B Taylor

John D Lambris

Florea Lupu

Gary Kinasewitz

Methods for the treatment of sepsis with complement inhibitors are disclosed. In particular, C3 inhibitors, such as Compstatin and Compstatin analogs, are administered at various times following the onset of sepsis to alleviate tissue damage and organ failure, which are hallmarks of the second, extravascular stage of sepsis. Combination therapies for comprehensive treatment of sepsis are also disclosed. Pharmaceutical compositions and kits for use in the methods are disclosed as well.

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Pinetops, NC, United States of America

Fletcher B Taylor