Thomas Jefferson University

Drexel University

Ge Precision Healthcare LLC

Flemming Forsberg

John Robert Eisenbrey

Barry B Goldberg

David Martin Mills

Margaret Alison Wheatley

Kirk Dennis Wallace

Joel S Raichlen

Noreen J Hickok

Lorenzo Albala

Patrick O'Kane

Steven Michael Kurtz

Christopher K Kepler

William Tao Shi

Ipshita Gupta

Alex Michael Sevit

Yunqiu Wu

The present invention relates to the use of contrast-enhanced ultrasound using microbubble-based ultrasound contrast agents to accomplish noninvasive subharmonic aided pressure estimation (SHAPE) in a region of interest (ROI) of a subject. The method of the invention provides a non-invasive, direct, and accurate method for pressure estimation.

Non-invasive method for pressure measurement

The invention relates to an ultrasound contrast agent (UCA) comprising an outer shell and a gas core. The gas core is filled with oxygen, and the outer shell comprises a first surfactant and a second surfactant. The invention also relates to a method of making an oxygen-filled UCA and delivering oxygen to a local area of a subject's body. The method comprises injecting a composition comprising an oxygen-filled UCA of the invention into the subject's body; directing ultrasound radiation to the local area in an intensity sufficient to rupture the UCA.

Surfactant microbubbles and process for preparing and methods of using the same

An implantable medical device having a sheath formed of a polymer material, wherein the sheath forms a reservoir attached to or around the implantable medical device, and wherein the reservoir is sealed with a biocompatible pressure responsive coating; wherein the biocompatible coating is stable for at least 7-day post implantation into a body, and can be mechanically ruptured by application of an exterior pressure generating force.

Antibiotic drug release sheath

The present invention relates to the use of diagnostic ultrasound and microbubble-based ultrasound contrast agents to accomplish noninvasive subharmonic aided pressure estimation (SHAPE) in the cavity of the heart, in other organs, and in major blood vessels. Diagnostic ultrasound provides noninvasive, real-time cross-sectional images and parameter estimations without ionizing radiation and without the disadvantages and risks of invasive methods of imaging and measurement. SHAPE is a non-invasive, direct, and accurate method for pressure estimation utilizing sub-harmonic or ultraharmonic signals from contrast agents. In light of the advantages of diagnostic ultrasound, SHAPE provides an economical alternative, a safe avenue, and an earlier timetable for assessing the clinical condition of patients, especially critically ill patients.

Method and system for pressure estimation using subharmonic signals from microbubble-based ultrasound contrast agents

The present invention relates generally to an ultrasound system and method, and more particularly to an excitation enhanced ultrasound system and method. The system employs at least one excitation signal as a 'flashlight' for exciting ultrasonic microbubbles contained in an ultrasound contrast agent. The system further employs at least one ultrasound imaging signal for imaging structures and blood flow within an object. The excitation signal excites and expands the microbubbles which increase the amount of returned ultrasound imaging signals scattered and returned by an object. This process increases the signal to noise ratio of the returning imaging signal sufficiently to provide exciter weighted imaging, blood pool imaging, and harmonic imaging, facilitating improved diagnostic ultrasound and therapeutic ultrasound.

Excitation enhanced ultrasound system

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Lafayette Hill, PA, United States of America

Flemming Forsberg