Aarhus Universitet

Region Midtjylland

Dupont Nutrition Biosciences Aps

Arhus Universitet

Cabra Technology A/s

Flemming Besenbacher

Karsten Matthias Kragh

Morten Foss

Jens Vinge Nygaard

Cody Eric Bünger

Finn Skou Pedersen

Jette Lovmand

Mogens Ryttergård Duch

Stepan Shipovskov

Ernst Martin Füchtbauer

Annette Christine Füchtbauer

Lotte Markert

Dang Quang Svend Le

Lea Bjerre

Jørgen Kjems

Samuel Alberg Kock

Brian Søgaard Lauresen

Duncan Sutherland

Won Yong Kim

Kenneth Alan Howard

Bent Deleuran

Jeannette Hoffmann Frisch Justesen

Lars Klembt Andersen

Trine Elkjaer Larsen Crovato

Mogens Ryttergard Duch

A method of making a three-dimensional biocompatible scaffold capable of supporting cell activities such as growth and differentiation, the method includes providing a supporting grid that forms an open network and provides mechanical support of a second biocompatible material. The second biocompatible material has interconnected cavities that allow nutrients, metabolites and soluble factors to diffuse throughout the scaffold. The scaffold design can be understood as a hierarchically organised structure. At the micron to submicron length scale a top/down manufacturing approach is used to make a structure that will constitute the frame into which a bottom/up processing approach is applied to form an open porous scaffold with specific nano sized features. The advantage of this hierarchically organised design is that benefits can be drawn independently from both the micron and the nano sized structures, promoting specific cell activities and providing sufficient mechanical compliance.

Three-dimensional nanostructured hybrid scaffold and manufacture thereof

A device for biological purposes such as cell culturing, enzymatic reactions or filtering of fluid has a body with first and second surfaces. The body is delimited by a rim and an aperture in the center of the body. The aperture is covered at the first and second surface by first and second plates. The first and/or second plate has an inlet orifice allowing liquid medium into the aperture. Rotating means are arranged in the aperture between the first and second plate. At least one recessed portion is a cavity in the rim of the body having a first outlet orifice allowing the liquid medium to flow out of the body. At least one outlet channel connects the circular aperture with the recessed portion. Liquid is pumped into the aperture of the device and pumped through at least one outlet channel.

Submerged perfusion bioreactor

A biocompatible material, wherein at least a part of a surface of the biocompatible material is characterized by a micro or nano-meter scale topographical structure comprising a plurality of features where the structure is selected to promote the growth of undifferentiated pluripotent stem cells or serve to promote the uniform differentiated growth of stem cells. Furthermore, a biocompatible material is provided having a surface structure and composition that affects a cellular function, in particular cellular functions related to gene induction, cell differentiation and the formation of bone tissue in vivo and ex-vivo.

Biocompatible materials for mammalian stem cell growth and differentiation

Growing community of inventors

Århus V, Denmark

Flemming Besenbacher