Novartis Ag

Flavio Ossola

Xiaodong Lin

Robert Lowell Simmons

Qingming Zhu

Folkert Reck

Guido Koch

Anthony Casarez

Markus Furegati

This invention pertains generally to compounds of Formula (A), as further described herein, which act as beta-lactamase inhibitors, and salts, crystalline forms and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds in combination with a beta-lactam antibiotic to treat infections caused by Gram-negative bacteria, including drug-resistant strains. 

Beta-lactamase inhibitors

This invention pertains generally to compounds of Formula (A), as further described herein, which act as beta-lactamase inhibitors, and salts, crystalline forms and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds in combination with a beta-lactam antibiotic to treat infections caused by Gram-negative bacteria, including drug-resistant strains.

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Basel, Switzerland

Flavio Ossola