Italfarmaco Spa

Flavio Leoni

Paolo Mascagni

Massimo Pinori

Gianni Gromo

Silvana Cappelletti

Patrizia Caretto

Antonio S Verdini

Giorgio Bertolini

Laura Gazerro

Mauro Biffi

Jacques Mizrahi

Teresa Sciumbata

Giuseppe Bottoni

Oreste Piccolo

Gianfranco Pavich

Fabrizio Marcucci

Flavio Somenzi

Francesco Autuori

Carlo Bianchini

Valmen Monzani

Maria Letizia Marchetti

Silvio Agozzino

Method of treating a tumor in a patient in need thereof by administering to the patient an effective amount of 4-[6-(diethylaminomethyl)naphth-2-ylmethyloxycarbamoyl]benzohydrozamic acid.

Use of hydroxamic acid derivatives for the preparation of anti-tumour medicaments

Stable, biologically compatible pharmaceutical compositions in the form of water-in-oil microemulsions (w/o), for the sustained release by parenteral administration of active ingredients which are hydrophilic or are made hydrophilic by suitable derivatization, a process for the preparation of said microemulsions and the use thereof.

Sustained release pharmaceutical compositions for the parenteral administration of hydrophilic compounds

The present invention relates to oligopeptide derived from fragments of the C-reactive protein (CRP), and to their use in the therapy of cardiovascular and inflammatory diseases.

Oligopeptides derived from C-reactive protein fragments

Heparin derivatives are disclosed that may be used to inhibit formation of metastases. One series of heparin derivatives of the invention are N-acylated with monocarboxylic acids or dicarboxylic acids and have molecular weights from about 1000 Daltons to about 30,000 Daltons. Another series of heparin derivatives of the invention have average molecular weights ranging from about 1000 to 3000 daltons, and are optionally N-acylated with residues from aliphatic monocarboxylic or dicarboxylic acids.

Heparin derivatives having antimetastatic activity

Compounds with anti-inflammatory and immunosuppressive activities

Analogues of the active metabolite of leflunomide, and to the use thereof as immunosuppressive and/or antinflammatory agents.

Analogues of the active metabolite of leflunomide

A method for treating septic shock by administering a retroinverted tetrapeptides of formula I ##STR1## wherein R is a hydrogen atom or the side-chain of threonine; R.sub.1 is the side-chain of arginine, leucine or glutamine; and R.sub.2 is a hydrogen atom or a metabolically perishable acyl group; with the proviso that when R.sub.1 is the side-chain of arginine, R cannot be the side-chain of threonine; diastereo-isomeric forms and pharmacologically acceptable salts, esters and amides thereof.

Partially modified and retro-inverted tetrapeptides analogues of

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Cinisello Balsamo, Italy

Flavio Leoni