Consejo Nacional De Investigaciones Cientificas Y Tecnicas (conicet)

Inis Biotech LLC

Consejo Nacional De Investigaciones Cientificas Y Tecnicas

Flavia Mariana Michelini

Javier Alberto Ramirez

Lydia Raquel Galagovsky

Alejandro Berra

Laura Edith Alche

A method of treating a solid tumor in a mammal by inhibiting angiogenesis, including administering to the mammal which has a solid tumor selected from the group consisting of breast carcinoma, lung carcinoma, prostate carcinoma, colon carcinoma, ovarian carcinoma, neuroblastoma, central nervous system tumor, multiform glioblastoma and melanoma; a composition including brassinosteroids of general formula (I) whereincan be a single or double bond and the configurations of carbon atoms C22 and C23 respectively linked to the substituents HO are S for both carbon atoms and a pharmaceutically acceptable additive.

Antiangiogenic brassinosteroid compounds

Brassinosteriods, illustrated by the following exemplary compounds, are disclosed:  The compounds have anti-inflammatory and antiviral activity. In pharmaceutical compositions, the compounds are useful in ophthalmic pharmaceuticals for treatment of diseases caused by adenovirus, such as epidemic keratoconjunctivitis, and herpes simplex type 1, such as herpetic stromal keratitis.

Compound showing anti-inflammatory activity and antiviral activity, pharmaceutical compositions comprising the same, a process for obtaining the same and use of the same in the treatment of epidemic keratoconjunctivites and herpetic stromal keratis

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Prov. de Buenos Aires, Argentina

Flavia Mariana Michelini