Consiglio Nazionale Delle Ricerche

Lay Line Genomics S.p.a.

Abbvie Inc.

Istituto Superiore Di Sanita

Flaminia Pavone

Gabriele Ugolini

Sara Marinelli

Mario Brufani

Antonino Cattaneo

Massimo Pomponi

Antonio Cattaneo

Alberto Oliverio

Maurizio Marta

Siro Luvisetto

Sara Martinelli

Claudio Castelland

Claudio Castellano

Valentina Vacca

Alessia Fabbri

Ugolini Gabriele

Loredana Falzano

Elisabetta Straface

Walter Malorni

Carla Fiorentini

A new therapeutic use of botulinum neurotoxin serotype A (Bont/A) is described, in the therapeutic treatment of paralysis caused by spinal cord injury.

Therapeutic use of the botulinum neurotoxin serotype A

Use of an anti-NGF antibody capable of inhibiting the binding between NGF and TrkA, capable of blocking the biological activity of TrkA for the preparation of a medicament for treating and/or preventing chronic pain.

Molecules that are able to inhibit the binding between NGF and the TrkA receptor as analgesics with prolonged effect

According to the invention there is provided use of an anti-TrkA antibody capable of inhibiting the binding between NGF and TrkA combined with at least one opioid analgesic for the preparation of a medicament for treating and/or preventing pain.

Method for the potentiation of opioid analgesics effects on pain

Use of an anti-TrkA antibody capable of inhibiting the binding between NGF and TrkA, in particular capable of blocking the biological activity of TrkA, for the preparation of a medicament for treating and/or preventing chronic pain.

Analgesic treatment with prolonged effect

Physostigmine derivatives with acetylcholinesterase inhibition properties, of general formula: ##STR1## in which R is a linear alkyl of from 2 to 20 C. atoms, a branched alkyl, a cycloalkyl or an aryl, when R' is H, or R and R' are linear alkyl of from 2 to 20 C. atoms.

Physostigmine derivatives with acetylcholinesterase inhibition

Physostigmine derivatives with acetylcholinesterase inhibition properties, of general formula: ##STR1## in which R is a linear alkyl of from 2 to 20 C atoms, a branched alkyl, a cycloalkyl or an aryl, when r' is H, or R and R' are linear alkyl of from 2 to 20 C atoms.

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Rome, Italy

Flaminia Pavone