Lupin, Inc.

Firoj Aftab Raje

Venkata Poornapragnacharyulu Palle

Rajender Kumar Kamboj

Neelima Sinha

Navnath Popat Karche

Anil Kashiram Hajare

Ajay Ramchandra Tilekar

Shridhar Keshav Adurkar

Baban Rupaji Thube

Bikramjit Singh Lairikyengbam

Disclosed is a compound of formula (I) wherein Y, Ring D, m and R-Rare as described herein, as a modulator of nicotinic acetylcholine receptors particularly the &#x3b1;7 subtype, in a subject in need thereof, as well as pharmaceutically acceptable salts, polymorphs, solvates, and isomers thereofs, for use either alone or in combinations with suitable other medicaments, and pharmaceutical compositions containing such compounds. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like. 

Thiazole derivatives as alpha 7 nAChR modulators

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Pune, India

Firoj Aftab Raje