Tufts University

University of Illinois

Boston University

University of Pennsylvania

Northwestern University

Canon Virginia, Inc.

Trustees of Trufts College

Fiorenzo G Omenetto

David L Kaplan

Brian D Lawrence

Mark Cronin-Golomb

Benedetto Marelli

Hu Tao

John A Rogers

Dae-Hyeong Kim

Jason Amsden

Mark A Brenckle

Gary G Leisk

Tim Jia-Ching Lo

Noorjahan A Panjwani

Miaomiao Yang

Jeffrey K Marchant

Sunghwan Kim

Konstantinos Tsioris

Brian Litt

Yonggang Huang

Luca Dal Negro

Irene Georgakoudi

Peter Tseng

Jonathan Viventi

Michele Muccini

Xin Zhang

Xiaoqin Wang

Raffaella Capelli

Richard Douglas Averitt

Svetlana Boriskina

Tuna Yucel

Stefano Toffanin

Mark Cronin-Golumb

Alexander Nicholas Mitropoulos

Lee W Tien

Suk-Won Hwang

Cinzia Metallo

Eleanor M Pritchard

Rak-Hwan Kim

Dana Cairns

Shenzhou Lu

Andrew Strikwerda

Roberto Zamboni

Valentina Benfenati

Benjamin P Partlow

Chunmei Li

Rodrigo R Jose

Jonathan A Kluge

Bradley Napier

Sarah Lightfoot Vidal

Logan Garbarini

Rosario Friedman

Rosalyn Abbott

Bruce Panilaitis

Matthew B Applegate

Giorgio E Bonacchini

Chengchen Guo

Joseph E Brown

Thomas Wheeless

Siwei Zhao

Kenichiro Iuchi

Samuele Battah

Jason J Amsden

Jordan Axelrad

James Amsden

Jeffrey Marchant

In some embodiments, the present disclosure provides methods including the steps of (i) providing silk fibroin material comprising substantially amorphous structure, and (ii) applying at least one of elevated temperature and elevated pressure to the silk fibroin material to form a silk fibroin article, wherein the applying induces fusion between at least a portion of the silk fibroin and structural change of fibroin in the silk fibroin material. In some embodiments, the present disclosure also provides silk fibroin articles made in accordance with the methods disclosed herein.

Compression and heat-assisted production of silk-based materials

Provided herein are methods and compositions for stabilization of active agents. The active agents are distributed, mixed or embedded in a silk fibroin matrix, thereby retaining the bioactivity of the active agents upon storage and/or transportation. In some embodiments, the storage-stable vaccine-silk compositions are also provided herein.

Compositions and methods for stabilization of active agents

Embodiments of the present disclosure provide a metadevice including a substrate, a resonator loop coupled to the substrate. The resonator loop having a first gap in the resonator loop. The metadevice includes an organic electrochemical transistor positioned in the first gap, a gate electrode, and an electrolyte extending between the organic electrochemical transistor and the gate electrode.

Microwave metadevice comprising a substrate having thereon a resonator loop with at least one gap and at least one electrochemical transistor disposed therein

A microneedle or microneedle device includes a microneedle body extending from a base to a penetrating tip formed from a silk fibroin based material, which is easy to fabricate and highly biocompatible. The microneedle device can include one or more microneedles mounted to a substrate. The silk fibroin can include active agents to be transported into or across biological barriers such as skin, tissue and cell membranes. The silk fibroin microneedles can be fully or partially biodegradable and/or bioerodible. The silk fibroin is highly stable, affords room temperature storage and is implantable. The silk fibroin structure can be modulated to control the rate of active agent delivery.

Silk fibroin-based microneedles and methods of making the same

The present application relates to silk fibroin-based hydrogels, methods for making and using the same.

Optically transparent silk hydrogels

The present disclosure provides a system and a method for automated extraction of silk fibroin from silk cocoons. The silk extraction system can include a boiling tank, a rinsing tank, and a rinse bowl attached to a robotic arm. The rinse bowl has a porous bottom surface adapted to retain an extracted silk fibroin. The robotic arm can move the rinse bowl between the boiling tank and the rinsing tank for separate stages of processing. A silk processing algorithm is executed by a processor to automate the process.

Automated process for silk fibroin extraction

The present disclosure provides a composition comprising a hierarchical opal that exhibits structural color when exposed to incident electromagnetic radiation. The hierarchical opal comprises nanoscale periodic cavities separated by a lattice constant, and includes a surface having grooves. The grooves may form a diffractive optical element on the surface of the hierarchical opal, such as a diffuser, a diffraction grating, a beamsplitter, a beam displacement opic, a Fresnel lens, and a micro lens, among others.

Hierarchical photonic crystals and methods of making the same

The present disclosure provides transparent, elastic silk hydrogels for applications, including corneal reshaping to restore visual acuity and photolithography. The present disclosure also provides methods of photocrosslinking silk fibroin protein using riboflavin as a photoinitiator and exposing such riboflavin doped silk fibroin to light resulting in the formation of a transparent, elastic hydrogel.

Silk-fibroin hydrogels, methods of forming, and uses thereof

The present disclosure provides certain silk-fibroin compositions with particular characteristics and/or properties. In some embodiments, the disclosure provides low molecular weight compositions. In some embodiments, the disclosure provides silk fibroin compositions that comprise an active (e.g., a biological) agent or component. In some embodiments, the disclosure provides low molecular weight silk fibroin compositions that comprise an active (e.g., a biological) agent or component. In some embodiments, an active agent is stabilized in a silk composition, e.g., for a period of time and/or against certain conditions or events. In some embodiments, a component present in a silk fibroin composition may be subject to analysis and/or characterization. In some embodiments, a component present in a silk fibroin composition may be recovered from the composition.

Low molecular weight silk compositions and stabilizing silk compositions

The present invention provides, in some embodiments, multi-layer silk compositions including a first layer comprising silk fibroin and keratinocytes, a second layer comprising silk fibroin and fibroblasts, a third layer comprising silk fibroin and adipocytes, and a plurality of nervous system cells, wherein at least some of the plurality of nervous system cells span at least two layers, and methods of making and using the same. In some embodiments, provided methods and compositions further include immune cells and/or endothelial cells.

Innervated artificial skin

Provided herein relates to implantable devices and systems with dynamic silk coatings. In some embodiments, the dynamic silk coatings can be formed in situ or in vivo.

Dynamic silk coatings for implantable devices

This present disclosure provides methods for utilizing such forces in when generating nanofibrillar constructs with engineered morphology from the nano- to macro-scales. Using for example, a biopolymer silk fibroin as a base material, patterns an intermediate hydrogel were generated within a deformable mold. Subsequently, mechanical tension was introduced via either hydrogel contraction or mold deformation, and finally a material is reentrapped in this transformed shape via beta-sheet crystallization and critical point drying. Topdown engineered anchorages, cables, and shapes act in concert to mediate precision changes in nanofiber alignment/orientation and a macroscale form of provided nanofibrillar structure. An ability of this technique to engineer large gradients of nano- and micro-scale order, manipulate mechanical properties (such as plasticity and thermal transport), and the in-situ generation of 2D and 3D, multi-tiered and doped, nanofibrillar constructs was demonstrated.

Biomimetic mechanical tension driven fabrication of nanofibrillar architecture

Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.

Biopolymer-based preservation of perishable products

Described herein are flexible and stretchable LED arrays and methods utilizing flexible and stretchable LED arrays. Assembly of flexible LED arrays alongside flexible plasmonic crystals is useful for construction of fluid monitors, permitting sensitive detection of fluid refractive index and composition. Co-integration of flexible LED arrays with flexible photodetector arrays is useful for construction of flexible proximity sensors. Application of stretchable LED arrays onto flexible threads as light emitting sutures provides novel means for performing radiation therapy on wounds.

Waterproof stretchable optoelectronics

This disclosure provides a dielectric sensor configured to detect a physiological variable within a subject. The dielectric sensor having at least one split-ring resonator configured to be positioned within an oral cavity of the subject and to be bioresponsive to at least one physiological variable. The split-ring resonator having a first resonator loop, a second resonator loop, and a dielectric interlayer interposed between and contacting the first resonator and the second resonator.

System and method of using a tooth antenna

Growing community of inventors

Lexington, MA, United States of America

Fiorenzo G Omenetto