The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth, Near Dublin

Inhibitex, Inc.

Universitá Degli Studi Di Pavia

Fiona Roche

Joseph M Patti

Timothy James Foster

Jeff T Hutchins

Pietro Speziale

Mark Pallen

Surface proteins are provided which generate polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positivebacteria, such asand to coagulase-negative bacteria, such asand. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common betweenand coagulase-negative staphylococci, or the A domains of those surface proteins, and these recombinant surface proteins are used to generate the cross-reactive antibodies. Vaccines comprising an immunologically effective amount of the proteins are also provided, and these vaccines are used in methods for the treatment or protection against a wide variety of staphylococcal infections.

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Polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such asand to coagulase-negative bacteria, such asand, are provided which can recognize surface proteins from both coagulase-positive and coagulase negative staph bacteria. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common betweenand coagulase-negative staphylococci, and these recombinant surface proteins are used to generate the antibodies of the invention. There is also provided vaccines and methods which utilize these proteins and antibodies for the treatment or protection against a wide variety of staphylococcal infections.

Cross-reactive monoclonal and polyclonal antibodies which recognize surface proteins from coagulase-negative staphylococci and Staphylococcus aureus

Growing community of inventors

Dublin, Ireland

Fiona Roche